7 documents found, page 1 of 1
Obesity: more than an inflammatory, an infectious disease?
Leocádio, Paola C. L.; Oriá, Reinaldo B.; Crespo-Lopez, Maria Elena; Alvarez-Leite, Jacqueline I.Much is discussed if obesity or diet components modify the “healthy” microbiota or if microbiota modifications trigger events that culminate in obesity. This association is probably reciprocal, and inflammation has crucial participation on it. We will discuss recent studies showing gut microbiome as an obesogenic factor and the mechanisms linked to the associated of diet, microbiota, and low-grade inflammation.
What Do Microglia Really Do in Healthy Adult Brain?
Augusto-Oliveira, Marcus; Arrifano, Gabriela P.; Lopes-Araújo, Amanda; Santos-Sacramento, Leticia; Takeda, Priscila Y.; Anthony, Daniel C.Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood without replacement by bone marrow-derived circulating cells. In inflammation, stroke, aging, or infection, microglia have been shown to contribute to brain pathology in both deleterious and beneficial ways, which have been studied extensively. However, less is known about their role in the healthy adult brain. Astrocyte...
Adult Hippocampal Neurogenesis in Different Taxonomic Groups: Possible Function...
Augusto-Oliveira, Marcus; Arrifano, Gabriela P F; Malva, João O.; Crespo-Lopez, Maria ElenaAdult neurogenesis occurs in many species, from fish to mammals, with an apparent reduction in the number of both neurogenic zones and new neurons inserted into established circuits with increasing brain complexity. Although the absolute number of new neurons is high in some species, the ratio of these cells to those already existing in the circuit is low. Continuous replacement/addition plays a role in spatial...
Unravelling motor behaviour hallmarks in intoxicated adolescents: methylmercury...
Oliveira, Aline Nascimento; Pinheiro, Alana Miranda; Bel?m-Filho, Ivaldo Jesus Almeida; Fernandes, Luanna Melo Pereira; Cart?genes, Sabrina CarvalhoThis work was funded by Funda??o Amaz?nia de Amparo a Estudos e Pesquisa do Par? (FAPESPA, grant number 160/2014 Edital 006/2014). Bel?m-Filho IJA and Nascimento AS received scholarships from Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES); Universidade Federal do Par?. Faculdade de Ci?ncias Farmac?uticas. Laborat?rio de Farmacologia da Inflama??o e do Comportamento. Bel?m, PA, Brazil.; Univ...
Hippocampal dysfunction provoked by mercury chloride exposure: evaluation of co...
Arag?o, Walessa Alana Bragan?a; Teixeira, Francisco Bruno; Fagundes, Nathalia Carolina Fernandes; Fernandes, Rafael MonteiroFederal University of Par?. Institute of Biological Sciences. Laboratory of Functional and Structural Biology. Bel?m, PA, Brazil.; Federal University of Par?. Institute of Biological Sciences. Laboratory of Functional and Structural Biology. Bel?m, PA, Brazil.; Federal University of Par?. Institute of Biological Sciences. Laboratory of Functional and Structural Biology. Bel?m, PA, Brazil.; Federal University of...
In the heart of the Amazon: noncommunicable diseases and apolipoprotein E4 geno...
Arrifano, Gabriela P. F.; Alvarez-Leite, Jacqueline I.; Souza-Monteiro, José Rogério; Augusto-Oliveira, Marcus; Paraense, Ricardo; Macchi, Barbarella M.The Amazon River basin is the largest tropical forest in the world. Most of the Amazon belongs to Brazil, a developing country that currently faces huge challenges related to the consolidation of its universal healthcare system. Noncommunicable diseases (NCDs) are the leading cause of death in Brazil, accounting for 74% of all deaths, and NCDs are probably underestimated in Amazonian population because of their...
Chronic intoxication by methylmercury leads to oxidative damage and cell death ...
Farias Junior, Paulo Mecenas Alves; Teixeira, Francisco Bruno; Fagundes, Nathalia Carolina Fernandes; Miranda, Giza Hellen NonatoFederal University of Par?. Institute of Biological Sciences. Laboratory of Functional and Structural Biology. Bel?m, PA, Brazil.; Federal University of Par?. Institute of Biological Sciences. Laboratory of Functional and Structural Biology. Bel?m, PA, Brazil.; Federal University of Par?. Institute of Biological Sciences. Laboratory of Functional and Structural Biology. Bel?m, PA, Brazil.; Federal University of...