4 documents found, page 1 of 1
Vitamin D loaded into lipid nanoparticles shows insulinotropic effect in INS-1E...
Cristelo, Cecília Silva; Sá, Ana Filipa Amorim; Lúcio, Marlene; Sarmento, Bruno; Gama, F. M.Increasing evidence suggests a beneficial role of vitamin D (VitD) supplementation in addressing the widespread VitD deficiency, but currently used VitD3 formulations present low bioavailability and toxicity constrains. Hence, poly(L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), solid-lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were investigated to circumvent these issues. PLGA NPs p...
The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility
Cristelo, Cecília Silva; Machado, Fátima Alexandra Meira; Sarmento, Bruno; Gama, F. M.Type 1 diabetes has increasingly greater incidence and prevalence with no cure available. Vitamin D supplementation is well documented to reduce the risk of developing type 1 diabetes. Being involved in the modulation of cathelicidin expression, the question whether cathelicidin may be one of the underlying cause arises. Cathelicidin has been implicated in both the development and the protection against type 1 ...
Bacterial cellulose-based microfluidic device for 3D skin modelling (skin-on-chip)
Gama, F. M.; Fortunato, Elvira; Sousa, Aureliana; Marques, Carolina; Leal, Ana Salomé Barbosa; Silvestre, Sara; Cristelo, Cecília SilvaPaper fluidics is based on patterning hydrophilic paper with channels bounded by hydrophobic barriers. Fluids move along channels by capillarity. Several methods are available for patterning paper, with different costs/resolutions. Paper patterning for microfluidics also used the embossing technique to design open-channel microfluidic devices, fabricated by compressing the sheet of paper with the help of 3D pla...
Surface modification of bacterial cellulose membranes for microfluidic applicat...
Silvestre, S. L.; Marques, A. C.; Cristelo, Cecília Silva; Gama, F. M.; Martins, R.; Fortunato, E.Although the great advances in medicine, there are still many limitations related to materials that can interact with the human body and its cells. One of the major challenges is developing biocompatible materials that can be used to skin repair treatments, tissue regeneration, inflammation, and wound treatments, among other problems. The most critical step to explore new materials development still remains in ...