3 documents found, page 1 of 1
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of ...
Cristiano Brigas, Maria Helena; Ribeiro, Miguel; Coelho, Joana E; Gomes, Rui; Gomez-Murcia, Victoria; Carvalho, Kevin; Faivre, EmilieNeuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has been recognized for decades, but the contribution of the recently described meningeal immune population to AD pathogenesis remains to be addressed. Here, using the 3xTg-AD model, we report an accumulation of interleukin-17 (IL-17)-producing cells, mostly γδ T cells, in the brain and the meninges of female, but not male, mic...
IL-17-producing gamma delta T cells in the pathophysiology of the Central Nervo...
Cristiano Brigas, Maria Helenaγδ T cells home to tissues and peripheral lymphoid organs where they strongly contribute to the immune response through the production of IFN-γ or IL-17. IL-17 producing γδ (γδ17) T cells, particularly, can be found in almost all barrier tissues in the body, being critical to protect their hosts against infections while being mostly pathogenic in autoimmune settings. More recently γδ17 T cells have been found t...
Microbiota-dependent expansion of testicular IL-17-producing Vγ6+ γδ T cells up...
Wilharm, Anneke; Cristiano Brigas, Maria Helena; Sandrock, Inga; Ribeiro, Miguel; Amado, Tiago; Reinhardt, Annika; Demera, Abdi; Hoenicke, LisaγδT cells represent the majority of lymphocytes in several mucosal tissues where they contribute to tissue homoeostasis, microbial defence and wound repair. Here we characterise a population of interleukin (IL) 17-producing γδ (γδ17) T cells that seed the testis of naive C57BL/6 mice, expand at puberty and persist throughout adulthood. We show that this population is foetal-derived and displays a T-cell recepto...