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Revolutionizing atrial fibrillation treatment: early results and future prospec...
Cortez-Dias, NunoAtrial fibrillation (AF) is the most common sustained arrhythmia in the population, and its treatment is a public health imperative due to its association with increased mortality and morbidity, including stroke, heart failure, and dementia. Early rhythm control strategies are the most effective way to prevent long-term adverse cardiovascular events. While antiarrhythmic drugs remain central to treatment, AF ab...
Preprocedural imaging guiding ventricular tachycardia ablation in structural he...
Ferreira, Afonso Nunes; Brito, Joana; Cortez-Dias, Nuno; Lima da Silva, Gustavo; Pinto, Fausto J.; De Sousa, JoãoBackground: Integration of preprocedural imaging techniques in ventricular tachycardia (VT) ablation may improve the identification of arrhythmogenic substrates, particularly relevant for patients with nonischemic cardiomyopathy (NICM) with sub-optimal outcomes. We assessed the impact of advanced preprocedural imaging on the safety and long-term efficacy of radiofrequency catheter ablation (RCA) for VT, compari...
Bloqueio percutâneo do gânglio estrelado por controlo ultrassonográfico no trat...
Galacho, João; Silva, Doroteia; Cortez-Dias, Nuno; Ribeiro, João MiguelA tempestade arrítmica é uma emergência médica que pode complicar a doença cardíaca estrutural grave e condiciona um risco acrescido de mortalidade. Os fármacos antiarrítmicos e a ablação por cateter são as terapêuticas mais comummente empregues. Como alternativa, o bloqueio percutâneo do gânglio estrelado sob controlo ecográfico é uma técnica promissora para o controlo da tempestade arrítmica em caso de refrat...
Quantitative assessment of myocardial fibrosis by digital image analysis: an ad...
Abecasis, João; Cortez-Dias, Nuno; Pinto, Daniel Gomes; Lopes, Pedro; Madeira, Márcio; Ramos, Sancia; Gil, Victor; Cardim, Nuno; Félix, AnaAIMS: Myocardial fibrosis (MF) is a common pathological process in a wide range of cardiovascular diseases. Its quantity has diagnostic and prognostic relevance. We aimed to assess if the complementary use of an automated artificial intelligence software might improve the precision of the pathologist´s quantification of MF on endomyocardial biopsies (EMB). Methods and results: Intraoperative EMB samples from 30...
Does a left common pulmonary trunk anatomy represent a real limitation for atri...
Brito, Joana; Rodrigues, Tiago; António, Pedro Silvério; Ferreira, Afonso Nunes; Lima Da Silva, Gustavo; Bernardes, Ana; Barreiros, Céu; Ribeiro, JoãoCryoballoon ablation (CBA) has been increasingly used for atrial fbrillation (AF) ablation. The presence of pulmonary vein (PV) anatomical variants, particularly left common pulmonary trunk (LCPT), may limit the cryoballoon adaptability and performance. To evaluate the impact of the presence of LCPT in CBA, we compared the success, safety, and procedure characteristics in consecutive patients referred for a frs...
Multielectrode mapping for premature ventricular contraction ablation: a prospe...
Sousa, Pedro A.; Barra, Sérgio; Cortez-Dias, Nuno; Khoueiry, Ziad; Paulo, José; António, Natália; Ferreira, Afonso Nunes; Pereira, MarianaPurpose: We aim to evaluate whether the use of a multielectrode mapping catheter could lead to higher efficacy of premature ventricular contraction (PVC) ablation. Methods: Prospective, multicenter nonrandomized study of consecutive patients referred for PVC ablation from January 2018 to June 2021. Patients were separated into two groups: activation map performed with the PentaRay catheter (Study group) or with...
Association between the number of altered late potential criteria and increased...
Brito, Joana; Cortez-Dias, Nuno; Lima Da Silva, Gustavo; Ferreira, Afonso Nunes; Aguiar-Ricardo, Inês; Cunha, Nelson; António, Pedro SilvérioBackground: Brugada syndrome (BrS) is associated with abnormal electrophysiological properties at right ventricular epicardium, consisting of fragmented electrograms extending well beyond QRS termination. We aimed to evaluate the utility of signal-averaged electrocardiogram (SA-ECG) for the noninvasive assessment of late potentials (LP) and risk stratification of BrS patients. Methods: A prospective, observatio...
Quantitative assessment of myocardial fibrosis by digital image analysis: an ad...
Abecasis, João; Cortez-Dias, Nuno; Pinto, Daniel Gomes; Lopes, Pedro; Madeira, Márcio; Ramos, Sancia; Gil, Victor; Cardim, Nuno; Félix, AnaAims: Myocardial fibrosis (MF) is a common pathological process in a wide range of cardiovascular diseases. Its quantity has diagnostic and prognostic relevance. We aimed to assess if the complementary use of an automated artificial intelligence software might improve the precision of the pathologist´s quantification of MF on endomyocardial biopsies (EMB). Methods and results: Intraoperative EMB samples from 30...
Impact of different activation wavefronts on ischemic myocardial scar electroph...
Lima Da Silva, Gustavo; Cortez-Dias, Nuno; Ferreira, Afonso Nunes; Nakar, Elad; Francisco, Raquel; Pereira, Mariana; Moreno, Javier; Martins, Raphaël P.Introduction: Scar-related ventricular tachycardia (VT) usually results from an underlying reentrant circuit facilitated by anatomical and functional barriers. The later are sensitive to the direction of ventricular activation wavefronts. We aim to evaluate the impact of different ventricular activation wavefronts on the functional electrophysiological properties of myocardial tissue. Methods: Patients with isc...
Implicações fisiopatológicas e valor prognóstico dos microRNAs nas doenças card...
Cortez-Dias, NunoA melhoria na compreensão da fisiopatologia das doenças cardiovasculares (DCV) tem permitido relevantes avanços diagnósticos e terapêuticos. Porém, o conhecimento dos mecanismos moleculares e celulares envolvidos permanece incompleto. Os microRNAs (miRNAs) são moléculas de ácido ribonucleico não-codificante que participam na regulação pós-transcripcional da expressão génica. Têm sido descritas anomalias na expr...