7 documents found, page 1 of 1
Detection of Drug Resistant Mycobacterium Tuberculosis Strains Using Kit SIRE N...
Miranda,Silvana Spindola de; Almeida,Isabela Neves de; Mansur,Maria de Fátima Filardi Oliveira; Figueredo,Lida Jouca de Assis; Carvalho,Wânia da SilvaAbstract (1) Background: The Commercial Kit SIRE Nitratase® PlastLabor, is a drug susceptibility test kit used to detect Mycobacterium tuberculosis resistance to first-line TB treatment drugs. The present study aimed at evaluating its performance in a multicenter study. (2) Methods: To determine its accuracy, the proportion methods in Lowenstein Jensen medium or the BACTECTMMGITTM960 system was used as a gold s...
Tuberculosis: renewed challenge in Brazil
Kritski,Afranio; Andrade,Kleydson Bonfim; Galliez,Rafael Mello; Maciel,Ethel Leonor Noia; Cordeiro-Santos,Marcelo; Miranda,Silvana SpindolaAbstract This article reviews tuberculosis control actions performed over the last decade, at a global level. The perspectives for the fulfillment of the goals of the new Global Tuberculosis Elimination Plan are described, where the insertion of social protection (Pillar 2) and research (Pillar 3) will play an innovative and strategic role, especially in high-burden countries, like Brazil.
Suicide in Brazilian indigenous communities: clustering of cases in children an...
Lazzarini,Thomas Adriano; Gonçalves,Crhistinne Cavalheiro Maymone; Benites,Walter Martins; Silva,Liliane Ferreira da; Tsuha,Daniel HenriqueABSTRACT OBJECTIVE To estimate age and sex-specific suicide rates, compare suicide rates between indigenous communities, and quantify the frequency of intrafamilial suicide clustering. METHODS We performed a retrospective cohort study involving 14,666 indigenous individuals in reservations in Dourados, state of Mato Grosso do Sul, Brazil, from 2003 through 2013 using national and local census. RESULTS The overa...
Frequency of indeterminate results from an interferon-gamma release assay among...
Oliveira,Sandra Maria do Valle Leone de; Trajman,Anete; Paniago,Anamaria Mello Miranda; Motta-Castro,Ana Rita Coimbra; Ruffino-Netto,AntonioABSTRACT Objective: To evaluate the frequency of and factors associated with indeterminate interferon-gamma release assay (IGRA) results in people living with HIV/AIDS (PLWHA). Methods: We tested 81 PLWHA in the central-west region of Brazil, using the tuberculin skin test and an IGRA. Information on sociodemographic and clinical variables was gathered through the use of questionnaires and from medical records....
Synthesis, in vitro Antiproliferative and Anti-Mycobacterium tuberculosis Activ...
Moreira,Flora M. F.; Croda,Julio; Sarragiotto,Maria H.; Foglio,Mary A.; Ruiz,Ana L. T. G.; Carvalho,João E.; Formagio,Anelise S. N.A series of β-carboline derivatives with amino or guanidinium were synthesized and evaluated in vitro against anti-Mycobacterium tuberculosis and for antiproliferative activities against nine human cancer cell lines. The compounds 1-(4-hydroxyphenyl)-3-carboxamide(ethylamine) β-carboline (24.9 µg mL-1) and 1-(4-methoxyphenyl)-3-carboxamide(ethylamine) β-carboline (26.9 µg mL-1) were the most active against M. T...
Chronic symptoms and pulmonary dysfunction in post-tuberculosis Brazilian patients
Nihues,Simone de Sousa Elias; Mancuzo,Eliane Viana; Sulmonetti,Nara; Sacchi,Flávia Patussi Correia; Viana,Vanessa de Souza; Martins Netto,EduardoABSTRACTBACKGROUND: Questionnaire and spirometry were applied to post-tuberculosis indigenous and non-indigenous individuals from Dourados, Brazil, to investigate the prevalence of chronic respiratory symptoms and pulmonary dysfunction.METHODS:This was a cross-sectional study in cured tuberculosis individuals as reported in the National System on Reportable Diseases (SINAN) from 2002 to 2012.RESULTS:One hundred...
Genetic polymorphism and immune response to tuberculosis in indigenous populati...
Longhi,Renata Maronna Praça; Zembrzuski,Verônica Marques; Basta,Paulo Cesar; Croda,JulioWe systematically reviewed studies of the immune response to tuberculosis and the genetic polymorphisms associated with Th1-or Th2-mediated cytokine expression in indigenous populations. A bibliographic search was performed on the Medline and ISI databases and included studies published between January 1980 and October 2011. The search terms were tuberculosis, American Indians, Amerindian, indigenous, Indians, ...