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Antisense Oligonucleotides Modulating Activation of a Nonsense-Mediated RNA Dec...
Kralovicova, J; Moreno, PM; Cross, N; Pêgo, AP; Vorechovsky, IATM (ataxia-telangiectasia, mutated) is an important cancer susceptibility gene that encodes a key apical kin ase in the DNA damage response pathway. ATM mutations in the germ line result in ataxia-telangiectasia (A-T), a rare genetic syndrome associated with hypersensitivity to double-strand DNA breaks and predisposition to lymphoid malignancies. ATM expression is limited by a tightly regulated nonsense-mediat...
Date: 2016
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Origin: Repositório Aberto da Universidade do Porto