5 documents found, page 1 of 1
PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated ...
Munari, Fernanda Franco; Cruvinel-Carloni, Adriana; Lacerda, Croider Franco; De Oliveira, Antônio Talvane Torres; Scapulatempo-Neto, CristovamMade available in DSpace on 2019-10-06T16:11:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-29; Background: Chronic diseases such as chagasic megaesophagus (secondary to Chagas' disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood. Objective: We analyzed hotspot PIK3CA gene mutations in a series...
PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated ...
Munari, Fernanda Franco; Cruvinel-Carloni, Adriana; Lacerda, Croider Franco; de Oliveira, Antônio Talvane Torres; Scapulatempo-Neto, CristovamChronic diseases such as chagasic megaesophagus (secondary to Chagas' disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood.
Absence of TERT promoter mutations in colorectal precursor lesions and cancer
Cruvinel-Carloni, Adriana; Yamane, Letícia; Scapulatempo-Neto, Cristovam; Guimarães, Denise; Reis, R. M.Hotspot mutations (c.-124bp G > A and c.-146bp G > A) in the promoter region of the TERT gene have been recently described in several types of solid tumors, including glioma, bladder, thyroid, liver and skin neoplasms. However, knowledge with respect to colorectal precursor lesions and cancer is scarce. In the present study we aimed to determine the frequency of hotspot TERT promoter mutations in 145 Brazilian ...
Molecular characterization of short-term primary cultures and comparison with c...
Cruvinel-Carloni, Adriana; Silva-Oliveira, Renato; Torrieri, Raul; Bidinotto, Lucas Tadeu; Berardinelli, Gustavo Noriz; Oliveira-Silva, Viviane AlineBackground: Glioblastoma, the most frequent and malignant adult brain tumor, has been extensively studied. However, there is no effective treatment, and to overcome this challenging scenario, it is essential to improve preclinical biological models. This study aimed to molecularly characterize short-term glioblastoma primary cultures and to compare them with patient tumor profiles. Methods: Glioblastoma cell li...
The prognostic impact of TERT promoter mutations in glioblastomas is modified b...
Batista, Rui; Cruvinel-Carloni, Adriana; Vinagre, João; Peixoto, Joana; Catarino, Telmo A.; Campanella, Nathalia Cristina; Menezes, WederHuman hotspot TERT promoter (TERTp) mutations have been reported in a wide range of tumours. Several studies have shown that TERTp mutations are associated with clinicopathological features; in some instances, TERTp mutations were considered as biomarkers of poor prognosis. The rs2853669 SNP, located in the TERT promoter region, was reported to modulate the increased TERT expression levels induced by the recurr...