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Neuroprotective effects of piperine, an alkaloid from the Piper genus, on the P...

Correia, Alyne Oliveira; Cruz, Abílio Augusto Pimentel; Aquino, Arôdo Tenório Ribeiro de; Diniz, Joanisson Rubens Gomes

Piperine (PIP), an alkaloid from the Piper genus plants, presents biological properties, including potent anti-inflammatory actions. Since neuroinflammation plays a key role in Parkinson's disease (PD), the objectives were to evaluate the neuroprotective activity of PIP in a model of PD. Male Wistar rats were divided as: sham-operated (SO), untreated 6-OHDA (lesioned in the right striatum) and 6-OHDA lesioned a...

Date: 2016   |   Origin: Oasisbr
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