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Ensuring safety in cytotoxic drug preparation: A systematic review of guideline...

Moreira, Fernando; Jesus, Ângelo; Pinho, Cláudia; Santos, Marlene; Serdoura, Mélanie; Cruz, Agostinho; Moreira, Fernando; Jesus, Ângelo; Pinho, Cláudia

Chemotherapy preparation involves the use of specific techniques and equipment, given the need to maintain preparation sterility and its strict prescribed composition, and avoid occupational exposure to cytotoxic agents. This study aims to identify the most relevant contents for pharmacy professionals' education and training programs and to elucidate the evaluation procedure these professionals should follow wh...


Innovative pedagogical tools for parasitology based on interactive learning

Sequeira, Susie; Sousa, Mariana; Fernandes, Sara; Barreiros, Luísa; Cunha, Agostinho; Cruz, Agostinho; Fernandes, Sara; Barreiros, Luisa

Parasitic infections in children, in particular ectoparasitoses, remain a public health challenge within the school context in Portugal. As part of the curricular unit “Agentes e Vectores de Doença I” included in the first year of the Bachelor of Pharmacy, pedagogical tools have been developed to raise awareness on this issue among the various stakeholders involved in primary education. The developed activities...


Exploring alternative potentialities of portuguese and spanish craft beers: ant...

Pereira, Maria João; Santos, Diana; Cruz, Agostinho; Jesus, Ângelo; Martins, João P.; Moreira, Fernando; Santos, Marlene; Pinho, Cláudia

Craft beer has gained popularity due to its unique sensory characteristics and complex matrix with nutritional and potential health benefits. Studies linking beer consumption to skin conditions are limited, however, the high content of bioactive compounds is related to biological activities such as antibacterial, anti-inflammatory, anti-oxidative, and anti-carcinogenic. This study aims to evaluate the antioxida...


Identification of barriers that can influence older adults in community pharmac...

Pedro, Rita; Mateos-Campos, Ramona; Cruz, Agostinho; Cruz, Agostinho

This systematic review examines the barriers that may influence the proper care and counseling for people who are 65 years or older, in community pharmacies. Also, we attempt to identify potential strategies to mitigate these barriers. The research question addressed is “What kind of barriers influence older people in community pharmacies?”. Five electronic databases were used: Medline from Pubmed, Core collect...


Exploring methodologies from Isolation to excystation for Giardia lamblia: A sy...

Sequeira, Susie; Sousa, Mariana; Cruz, Agostinho; Cruz, Agostinho

Giardia lamblia is a flagellated protozoan and the etiological agent of giardiasis, a leading cause of epidemic and sporadic diarrhoea globally. The clinical and public health relevance of giardiasis underscores the need for robust methodologies to investigate and manage this pathogen. This study reviews the main methodologies described in the literature for studying the life cycle of G. lamblia, focusing on is...


Use of Medicinal Plants for Treatment and Prophylaxis of Canine Parasitic Infec...

Santos, Patrícia; Sousa, Mariana; Cruz, Agostinho; Cruz, Agostinho

Dogs have been perceived as providing companionship to all members of the family, yet they can act as a vector for the transmission of parasitic agents to humans, particularly those who own or care for them. Traditional medicine seem to demonstrate effects in the treatment of diseases in animals; however, it is necessary to prove their effectiveness using more recent scientific evidence.


Policy measures and instruments used in European countries to increase biosimil...

Machado, Sara ; Cruz, Agostinho; Ferreira, Pedro Lopes ; Morais, Carminda ; Pimenta, Rui

While biosimilar medicines can contribute to the sustainability of healthcare systems, their utilization rate varies across European countries. This study aims to identify and systematize policy measures and instruments used in European countries to increase biosimilar market share. A systematic review was conducted according to PRISMA 2020 recommendations. Medline-PubMed, Web of Science and ScienceDirect datab...


Polypharmacy and drug interactions in older patients with cancer receiving chem...

Ferraz Oliveira, Rita; Oliveira, Ana Isabel; Cruz, Agostinho; Ribeiro, Oscar; Afreixo, Vera; Pimentel, Francisco

Polypharmacy in older adults with cancer receiving chemotherapy leads to increased risks of drug interactions, translating in potential hazardous health outcomes. This study aims to assess the prevalence of polypharmacy, drug–drug interactions (DDIs), and severe-drug interactions (SDIs) in older patients with cancer. Antineoplastic agents (ANAs) involvement and possible risk contexts (comorbidities with cardiac...


Systematic review of the uses of Cortaderia selloana (Poaceae), an invasive plant

Teixeira, Jéssica; Sousa, Mariana; Cruz, Agostinho; Cruz, Agostinho

Cortaderia selloana, commonly known as Pampas Grass, manifests as an invasive plant across numerous countries with predominant studies focused on its control measures (physical, biological, and chemical approaches). Native to South America, this perennial tussock grass negatively impacts economic, environmental, and human health. This study aims to explore the diverse uses of Cortaderia selloana in geographical...


ABCB1 C1236T, G2677TA and C3435T genetic polymorphisms and antidepressant respo...

Santos, Marlene; Lima, Luís; Carvalho, Serafim; Brandão, Andreia; Barroso, Fátima; Cruz, Agostinho; Medeiros, Rui

P-glycoprotein (P-GP) is a transporter molecule expressed on the apical surface of capillary endothelial cells of the Blood–Brain Barrier (BBB), whose activity heavily influences drug distribution, including antidepressants. This transporter is encoded by ABCB1 gene, and genetic variations within ABCB1 gene have been proposed to affect drug efflux and have been previously associated with depression. In this con...


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