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Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in Sjögren's...

Barcelos, Filipe; Abreu,  Isabel; Patto, José Vaz; Trindade, Helder; Teixeira, Ana

Objectives: The purpose of this study was to evaluate the prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies (anti-CCP-Abs), IgM and IgA rheumatoid factors (RFs) in primary Sjogren's Syndrome (pSS). Materials and Methods:We compared clinical and serological. characteristics of 31 pSS and 31 Rheumatoid Arthritis (RA) patients. Both, anti-CCP-Abs and RFs (IgM, IgA) directed again...


ST3Gal.I sialyltransferase relevance in bladder cancer tissues and cell lines

Videira, Paula A.; Correia, Manuela; Malagolini, Nadia; Crespo, Hélio J.; Ligeiro, Dário; Calais, Fernando M.; Trindade, Helder; Dall'Olio, Fabio

Background: The T antigen is a tumor-associated structure whose sialylated form (the sialyl-T antigen) involves the altered expression of sialyltransferases and has been related with worse prognosis. Since little or no information is available on this subject, we investigated the regulation of the sialyltransferases, able to sialylate the T antigen, in bladder cancer progression. Methods: Matched samples of uro...


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