8 documents found, page 1 of 1
The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models
Neto, AC; Santos Pereira, M; Abreu Mendes, P; Neves, D; Almeida, H; Cruz, F; Charrua A.<jats:p>The different definitions of chronic pelvic/visceral pain used by international societies have changed over the years. These differences have a great impact on the way researchers study chronic pelvic/visceral pain. Recently, the role of systemic changes, including the role of the central nervous system, in the perpetuation and chronification of pelvic/visceral pain has gained weight. Consequently, rese...
Effect of Water Avoidance Stress on serum and urinary NGF levels in rats: diagn...
Dias, B; Serrão, P; Cruz, F; Charrua, ANerve growth factor (NGF) is thought to play a key role in chronic pain felt by bladder pain syndrome/interstitial cystitis (BPS/IC) patients by activating its high affinity receptor tropomyosin-related kinase subtype A (Trk A). Whether this pathway is also involved in the aggravation of pain sensation during stress events was here investigated. The levels of plasmatic NGF were increased in rats submitted to Wa...
Tracking of food and nutrient intake from adolescence into early adulthood
Cruz, F; Ramos, E; Lopes, C; Araújo, JObjective: According to the dietary patterns identified in adolescence, we assessed the tracking of food and nutrient intake between adolescence and early adulthood. Methods: Participants were 962 adolescents from the Epidemiologic Health Investigation of Teenagers in Porto (EPITeen) cohort, with dietary patterns assigned at 13 y and valid information on diet at 21 y. In both waves, diet was evaluated by a food...
Can serum angiogenin be used to improve the diagnostic performance in prostate ...
Pina, F; Botelho, F; Lopes, T; Lopes, I; Figueiredo, G; Portugal, R; Ferro, A; Cruz, F; Barros, H; Lunet, NSeveral biomarkers have been studied to avoid unnecessary biopsies resulting from suboptimal performance of prostate-specific antigen (PSA) testing. We aimed to assess the use of serum angiogenin as a prostate cancer diagnostic tool among candidates for biopsy. We selected 252 patients referred for ultrasound-guided transrectal prostate biopsy on the basis of an abnormal digital rectal examination and/or elevat...
Endothelial function in patients with metabolic syndrome and erectile dysfuncti...
Tomada, N; Tomada, I; Botelho, F; Pacheco-Figueiredo, L; Lopes, T; Negrão, R; Pestana, M; Cruz, FErectile dysfunction (ED) is a highly prevalent disease whose aetiology is mostly vasculogenic. It is nowadays considered a marker of future cardiovascular events reflecting the underlying endothelial dysfunction, the common link with the metabolic syndrome (MetS). The recent association between MetS, endothelial dysfunction and peripheral artery disease, but not with coronary artery disease (CAD), suggests tha...
Does baseline total testosterone improve the yielding of prostate cancer screen...
Botelho, F; Pina, F; Figueiredo, L; Cruz, F; Lunet, NPrevious studies suggest an association between total testosterone (tT) and prostate cancer, but results are conflicting and it is not clear if accounting for the tT levels improves the yielding of patient selection for prostatic biopsy. We evaluated the potential for tT levels and the tT/total PSA (tPSA) ratio to be used as diagnostic tools for prostate cancer and its relation with cancer aggressiveness. We me...
Vascular endothelial growth factor (VEGF) and prostate pathology
Botelho, F; Pina, F; Silva, P; Figueiredo, G; Cruz, F; Lunet, NPurpose: Previous studies suggest that vascular endothelial growth factor (VEGF) circulating levels might improve identification of patients with prostate cancer but results are conflicting. Our aim was to compare serum VEGF levels across different prostate pathologies (including benign prostatic hyperplasia, prostatitis, high grade prostate intraepithelial neoplasia and prostate cancer) in patients at high ris...
Symptoms of the lower urinary tract which suggest cystitis.
Cruz, FAcute bacterial cystitis is a very common disease of the lower urinary tract, in particular among women with an active sex life. Symptoms include dysuria, frequency, nocturia and urgency. As these symptoms are nonspecific, acute bacterial cystitis should be distinguished from more severe urinary tract conditions by an appropriate medical history.; Acute bacterial cystitis is a very common disease of the lower u...