17 documents found, page 1 of 2
Surgical aortic valve replacement in octogenarians: single-center perioperative...
Velho, Tiago R.; Goncalves, Joao; Pereira, Rafael Maniés; Ferreira, Ricardo; Sena, André; Junqueira, Nádia Viviana; Ângelo, EurídiceIntroduction and objectives: Aortic stenosis is the most common valvular heart disease. The number of octogenarians proposed for intervention is growing due to increased lifespan. In this manuscript we aim to evaluate perioperative outcome and long-term survival after surgical aortic valve replacement (SAVR) in octogenarians, comparing patients with low surgical risk (EuroscoreII <4%) with intermediate-high ris...
Sutureless bioprosthesis for aortic valve replacement: surgical and clinical ou...
Ferreira, Ricardo; Rua, Nuno; Sena, André; Velho, Tiago R.; Goncalves, Joao; Junqueira, Nádia; Almeida, Ana G.; Nobre, Angelo; Pinto, Fausto J.Background: Aortic valve stenosis is the most common adult valve disease in industrialized countries. The aging population and the increase in comorbidities urge the development of safer alternatives to the current surgical treatment. Sutureless bioprosthesis has shown promising results, especially in complex procedures and in patients requiring concomitant surgeries. Objectives: Assess the clinical and hemodyn...
Origin, phylogeny, variability and epitope conservation of SARS-CoV-2 worldwide
Vale, Filipa F.; Vítor, Jorge M. B.; Marques, Andreia T.; Azevedo-Pereira, José Miguel; Anes, Elsa; Goncalves, JoaoThe coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses innumerous challenges, like understanding what triggered the emergence of this new human virus, how this RNA virus is evolving or how the variability of viral genome may impact the primary structure of proteins that are targets for vaccine. We analyzed 19471 SARS-CoV-2 genomes availa...
New LncRNAs in Chronic Hepatitis C progression: from fibrosis to hepatocellular...
Ferrasi, Adriana Camargo [UNESP]; Fernandez, Geysson Javier; Grotto, Rejane Maria Tommasini [UNESP]; Silva, Giovanni Faria [UNESP]; Goncalves, JoaoMade available in DSpace on 2020-12-12T02:11:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death in the world, and about 80% of the cases are associated with hepatitis B or C. Genetic and epigenetic alterations are accumulated over decades of chronic injury and may affect the functioning of tumor suppressor genes and ...
Celastrol efficacy by oral administration in the adjuvant-induced arthritis model
Cascao, Rita; Vidal, Bruno; Carvalho, Tânia; Lopes, Inês; Romão, Vasco C.; Goncalves, Joao; Moita, Luis; Fonseca, João EuricoBackground: We previously demonstrated that celastrol has significant anti-inflammatory and bone protective effects when administered via the intraperitoneal route. For further preclinical evaluation, an effective oral administration of celastrol is crucial. Here we aimed to study the therapeutic dose range for its oral administration. Methods: Celastrol (1-25 μg/g/day, N = 5/group) was administrated orally to ...
Anti-HIV-1 Activity of pepRF1, a Proteolysis-Resistant CXCR4 Antagonist Derived...
Cadima Couto, Carla Iris; Tauzin, Alexandra; Freire, João Miguel; Figueira, Tiago N.; Silva, Rúben; Pérez-Peinado, Clara; Cunha-Santos, CatarinaThere is an urgent need for the development of new anti-HIV drugs that can complement existing medicines to be used against resistant strains. Here, we report the anti-HIV-1 peptide pepRF1, a human serum-resistant peptide derived from the Dengue virus capsid protein. In vitro, pepRF1 shows a 50% inhibitory concentration of 1.5 nM with a potential therapeutic window higher than 53 000. This peptide is specific f...
Systematic review and principal components analysis of the immunogenicity of Ad...
Borrega, Rodrigo; Araujo, Carlos; Aguiam, Nádia Romeu; Magro, Fernando; Fonseca, João Eurico; Danese, Silvio; Lopes, João A; Goncalves, JoaoBackground: The reported immunogenicity rates of adalimumab differ significantly between studies because of a wide variety of factors related to the disease, patients, study design, and products. Objective: The objective of this study was to characterize this variability and identify the major factors that contribute to these fluctuations. Methods: A systematic literature review was conducted using the MEDLINE,...
Anti-HIV-1 activity of pepRF1, a proteolysis-resistant CXCR4 antagonist derived...
Cadima Couto, Carla Iris; Tauzin, Alexandra; Freire, João Miguel; Figueira, Tiago N.; Silva, Rúben D. M.; Pérez-Peinado, Clara; Cunha-Santos, CatarinaThere is an urgent need for the development of new anti-HIV drugs that can complement existing medicines to be used against resistant strains. Here, we report the anti-HIV-1 peptide pepRF1, a human serum-resistant peptide derived from the Dengue virus capsid protein. In vitro, pepRF1 shows a 50% inhibitory concentration of 1.5 nM with a potential therapeutic window higher than 53 000. This peptide is specific f...
Biosimilars in rheumatology
Araújo, Filipe C.; Goncalves, Joao; Fonseca, João EuricoBiotechnologicals are an invaluable resource in the treatment of patients with inflammatory rheumatic diseases (IRD) non-responsive or intolerant to conventional therapies. However, they are the main driver for increase in direct costs and represent a significant economic burden to healthcare systems worldwide. Since biosimilars are similar and more affordable versions of previously licenced biotechnologicals, ...
Improved serological detection of rheumatoid arthritis: a highly antigenic mimo...
Araujo, Galber Rodrigues; Vaz, Emília Rezende; Fujimura, Patricia Tiemi; Fonseca, João Eurico; de Lima, Lucélia Maria; Canhao, HelenaIntroduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects around 1% of the human population worldwide. RA diagnosis can be difficult as there is no definitive test for its detection. Therefore, the aim of this study was to identify biomarkers that could be used for RA diagnosis. Methods: Sera from a collagen-induced arthritis mouse model were used to select potential biom...