4 documents found, page 1 of 1
Quinolin-(1H)-imines as a new chemotype against leishmaniasis: biological evalu...
Alves, Ana G. Gomes; Duarte, Margarida; Cruz, Tânia; Castro, Helena; Lopes, Francisca; Moreira, Rui; Ressurreição, Ana S.; Tomás, Ana M.Leishmaniasis is one of the most challenging neglected tropical diseases and remains a global threat to public health. Currently available therapies for leishmaniases present significant drawbacks and are rendered increasingly inefficient due to parasite resistance, urging the need for more effective, safer, and cheaper drugs. In our efforts to identify novel chemical scaffolds for the development of antileishm...
Relatório de Estágio Curricular - CERCIG - Cooperativa de Educação e Reabilitaç...
Cruz, TâniaRealizei o meu estágio na Cooperativa de Educação e Reabilitação de Cidadãos Inadaptados da Guarda (CERCIG), no âmbito do término do curso técnico superior em gerontologia, com a duração de setecentas e cinquenta horas. A CERCIG é uma instituição sem fins lucrativos e reconhecida como uma entidade pública que intervém junto de grupos mais vulneráveis com o intuito de defender os seus direitos individuais e de c...
Development of an automated image analysis protocol for quantification of intra...
Alves, Ana G. Gomes; Maia, André F.; Cruz, Tânia; Castro, Helena; Tomás, Ana M.Leishmania parasites cause a set of neglected tropical diseases with considerable public health impact, the leishmaniases, which are often fatal if left untreated. Since current treatments for the leishmaniases exhibit high toxicity, low efficacy and prohibitive prices, many laboratories throughout the world are engaged in research for the discovery of novel chemotherapeutics. This entails the necessity of scre...
Studies in the mouse model identify strain variability as a major determinant o...
Marques, Filipe; Vale-Costa, Sílvia; Cruz, Tânia; Marques, Joana Moreira; Silva, Tânia; Neves, João Vilares; Cortes, Sofia; Fernandes, AnaVisceral leishmaniasis is a severe and potentially fatal disease caused by protozoa of the genus Leishmania, transmitted by phlebotomine sandflies. In Europe and the Mediterranean region, L. infantum is the commonest agent of visceral leishmaniasis, causing a wide spectrum of clinical manifestations, including asymptomatic carriage, cutaneous lesions and severe visceral disease. Visceral leishmaniasis is more f...