2 documents found, page 1 of 1
The semisynthetic landscape of aphidicolin: inspiration towards leishmanicidal ...
Santos,Gabriela B.; Almeida,Marília O.; Cardoso,Iara A.; Manfrim,Viviane; Chagas,Fernanda O.; Toledo,Juliano S.; Pinzan,Camila C.Recent studies have shown that aphidicolin, a secondary metabolite of the endophytic fungus Nigrospora sphaerica, has high activity against the protozoan Leishmania major. Despite its promising leishmanicidal potential, aphidicolin presents a therapeutically unsuitable physico-chemical and pharmacokinetic profile. In this sense, a review of the literature shows the limited types of modification for this terpene...
Bioactive extracts and chemical constituents of two endophytic strains of Fusar...
Nascimento,Andréa M. do; Conti,Raphael; Turatti,Izabel C. C.; Cavalcanti,Bruno C.; Costa-Lotufo,Letícia V.; Pessoa,Cláudia; Moraes,Manoel O. deEthyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based o...