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Candida albicans: the current status regarding vaginal infections
Faustino, Margarida; Ferreira, Carlos M. H.; Pereira, Ana Margarida; Carvalho, Ana P.Vaginal infections caused by Candida albicans are a significant global health concern due to their recurrence and negative impact on quality of life. This review examines the pathogenesis of C. albicans infections, emphasizing critical virulence factors such as biofilm formation, adherence, and phenotypic switching. Risk factors include immune system suppression, antibiotic use, and hormonal changes, all of whi...
Up-scalable approaches for yeast mannan oligosaccharides (MOS) production: char...
Faustino, Margarida; Durão, Joana; Pereira, Carla F.; Pereira, Ana Margarida; Oliveira, Ana Sofia; Sousa, Sérgio; Ribeiro, Alessandra BragaMannan oligosaccharides (MOS) are widely used as feed additives due to their effects on gut microbiome modulation. Its application in the nutraceutical and functional food industries is also increasing. Numerous studies portraying MOS production from β-mannans can be found, but its production from yeast mannans is barely explored. Herein, two up-scalable approaches to produce yeast-derived MOS are presented: hy...
Vaginal prevention of Candida albicans: synergistic effect of lactobacilli and ...
Faustino, Margarida; Pereira, Joana Odila; Pereira, Ana Margarida; Oliveira, Ana Sofia; Ferreira, Carlos M. H.; Pereira, Carla F.; Durão, JoanaVulvovaginal candidiasis (VVC) affects approximately 30-50% of women at least once during their lifetime, causing uncomfortable symptoms and limitations in their daily quality of life. Antifungal therapy is not very effective, does not prevent recurrencies and usually causes side effects. Therefore, alternative therapies are urgently needed. The goal of this work was to investigate the potential benefits of usi...
Use of various sugarcane byproducts to produce lipid extracts with bioactive pr...
Pereira, Joana Odila; Oliveira, Diana; Faustino, Margarida; Vidigal, Susana S. M. P.; Pereira, Ana Margarida; Ferreira, Carlos M. H.Sugarcane, a globally cultivated crop constituting nearly 80% of total sugar production, yields residues from harvesting and sugar production known for their renewable bioactive compounds with health-promoting properties. Despite previous studies, the intricate interplay of extracts from diverse sugarcane byproducts and their biological attributes remains underexplored. This study focused on extracting the lipi...
Effect of mannan oligosaccharides extracts in uropathogenic escherichia coli ad...
Faustino, Margarida; Silva, Sara; Costa, Eduardo M.; Pereira, Ana Margarida; Pereira, Joana Odila; Oliveira, Ana Sofia; Ferreira, Carlos M. H.Urinary tract infections (UTIs) are a common public health problem, mainly caused by uropathogenic Escherichia coli (UPEC). Patients with chronic UTIs are usually treated with long-acting prophylactic antibiotics, which promotes the development of antibiotic-resistant UPEC strains and may complicate their long-term management. D-mannose and extracts rich in D-mannose such as mannan oligosaccharides (MOS; D-mann...
Iron-peptide complexes from spent yeast: evaluation of iron absorption using a ...
Oliveira, Ana Sofia; Ferreira, Carlos M. H.; Pereira, Joana Odila; Silva, Sara; Costa, Eduardo M.; Pereira, Ana Margarida; Faustino, MargaridaAnaemia is one of the most prevalent nutritional diseases worldwide with Fe deficiency being its major cause. In fact, the limited bioavailability of dietary iron and its interaction with food compounds contribute to its poor absorption in the human body and dietary Fe supplementation has been widely used to address this issue. By incorporating a circular economy framework, this study takes a novel approach of ...
Production of iron-peptide complexes from spent yeast for nutraceutical industry
Oliveira, Ana Sofia; Ferreira, Carlos M. H.; Pereira, Joana Odila; Sousa, Sérgio; Faustino, Margarida; Durão, Joana; Pereira, Ana MargaridaIron (Fe) deficiencies are a major health condition concern and over the years many solutions in the form of Fe supplementation have been investigated. Organic Fe-complexes are the most promising for Fe deficiencies remediation. The aim of present study was to value peptide rich waste streams from β-glucan and mannan production from spent yeast (Gpep and Mpep, respectively) as Fe-peptide complexes for Fe supple...
Comparison of five bacterial strains producing siderophores with ability to che...
Ferreira, Carlos M. H.; Vilas-Boas, Ângela; Sousa, Cátia A.; Soares, Helena M. V. M.; Soares, Eduardo V.Iron deficiency is one of the main causes of chlorosis in plants, which leads to losses in field crops quality and yield. The use of synthetic chelates to prevent or correct iron-deficiency is not satisfactory mainly due to their poor biodegradability. The present work aimed to search suitable microorganisms to produce alternative, environment-friendly iron-chelating agents (siderophores). For this purpose, the...
Evaluation of the Efficacy of Two New Biotechnological-Based Freeze-Dried Ferti...
Ferreira, Carlos M. H.; López-Rayo, Sandra; Lucena, Juan J.; Soares, Eduardo V.; Soares, Helena M. V. M.Currently, fertilization with synthetic chelates is the most effective agricultural practice to prevent iron (Fe) deficiencies in crops, especially in calcareous soils. Because these compounds are not biodegradable, they are persistent in the environment, and so, there is the risk of metal leaching from the soils. Thus, new, more environment-friendly efficient solutions are needed to solve iron-deficiency-induc...
Comparison of five bacterial strains producing siderophores with ability to che...
Ferreira, Carlos M. H.; Vilas-Boas, Ângela; Sousa, C. A.; Soares, Helena M. V. M.; Soares, Eduardo V.Iron deficiency is one of the main causes of chlorosis in plants, which leads to losses in field crops quality and yield. The use of synthetic chelates to prevent or correct iron-deficiency is not satisfactory mainly due to their poor biodegradability. The present work aimed to search suitable microorganisms to produce alternative, environment-friendly iron-chelating agents (siderophores). For this purpose, the...