5 documents found, page 1 of 1
Efeito Hipoglicemiante de um Extracto Aquoso de Cytisus multiflorus
Vieira, Ines P.; Costa, Ana Rodrigues; Teixeira, Dora M.; Antunes, Celia M.; Cruz-Morais, JulioEfeito Hipoglicemiante de um Extracto Aquoso de Cytisus multiflorus I. P. Vieira1, A. C. Costa1,2, D. M. Teixeira1,2,3, C. M. Antunes1,4 & J. Cruz-Morais1,2 1Departamento de Química; 2Instituto de Ciências Agrárias e Ambientais Mediterrânicas (ICAAM), 3Laboratório Hércules, Universidade de Évora, Largo dos Colegiais 2, 7000 Évora; 4Centro de Neurociências e Biologia Celular (CNC), Universidade de Coimbra, 3004-...
Alterações na modulação da Na,K-ATPase pela glicose em célula β-pancreática de ...
Costa, Ana Rodrigues; Antunes, Célia M.; Cruz-Morais, JulioAlterações na modulação da Na,K-ATPase pela glicose em célula β-pancreática de animais intolerantes à glicose AR Costa1,2, CM Antunes1,3, J Cruz-Morais1,2 1Departamento de Química, 2Instituto de Ciências Agrárias e Ambientais Mediterrânicas (ICAAM), Universidade de Évora, Largo dos Colegiais 2, 7000 Évora; 3Centro de Neurociências e Biologia Celular (CNC), Universidade de Coimbra, 3004-517 Coimbra;.acrc@uevora....
Abnormal regulation of Na,K-ATPase in Glucose Intolerant Rats.
Costa, Ana Rodrigues; Antunes, Célia M.; Cruz-Morais, JulioIntroduction: Glucose is the most important physiological insulin secretagogue. However, the mechanisms underlying glucose-induced insulin release are not fully understood. The role of electrogenic systems such as ionic pumps, to these events remains essentially uninvestigated. Na,K-ATPase, responsible for maintaining Na+ and K+ gradients across the plasma membrane and generates a net outward current, thus chan...
Chemical composition and anti-diabetic properties of Cytisus multiflorus
Vieira, Ines P.; Costa, Ana Rodrigues; Teixeira, Dora M.; Antunes, Celia M.; Cruz-Morais, JulioBakground and aims: The interest on plants with potential medicinal properties has been increasing worldwide. In the Iberian Peninsula there are some endemic species known by the population for their pharmacologic activity with valorization potential that have not been yet characterized. The white Spanish broom (Cytisus multiflorus) is described as having anti-diabetic effect [1] and in a preliminary the hypogl...
Implication of AMPK in glucose-evoked modulation of Na,K-ATPase
Costa, Ana Rodrigues; Antunes, Célia M.; Cruz-Morais, JulioBackground and aims: Na,K-ATPase is an integral membrane protein that maintains the gradients of Na+ and K+, using the energy of ATP hydrolysis, maintaining the ionic gradients that allow electrical activity to occur. It has been demonstrated that, in pancreatic β-cells, Na,K-ATPase is regulated by glucose and that this phenomenon is impaired in glucose intolerant subjects. However, the mechanism underlying glu...