29 documents found, page 1 of 3
2020 Brazilian Thoracic Association recommendations for the management of asthma
Pizzichini,Marcia Margaret Menezes; Carvalho-Pinto,Regina Maria de; Cançado,José Eduardo Delfini; Rubin,,Adalberto Sperb; Cerci Neto,AlcindoABSTRACT The pharmacological management of asthma has changed considerably in recent decades, as it has come to be understood that it is a complex, heterogeneous disease with different phenotypes and endotypes. It is now clear that the goal of asthma treatment should be to achieve and maintain control of the disease, as well as to minimize the risks (of exacerbations, disease instability, accelerated loss of lu...
Symptom variability over the course of the day in patients with stable COPD in ...
Cukier,Alberto; Godoy,Irma de; Costa,Claudia Henrique da; Rubin,Adalberto Sperb; Gregorio,Marcelo Gervilla; Albuquerque Neto,Aldo Agra deABSTRACT Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean ...
Characterization of the severity of dyspnea in patients with bronchiectasis: co...
Nucci,Maria Cecília Nieves Maiorano de; Fernandes,Frederico Leon Arrabal; Salge,João Marcos; Stelmach,Rafael; Cukier,Alberto; Athanazio,RodrigoABSTRACT Objective: To characterize a population of patients with bronchiectasis, correlating clinical, radiological, and functional aspects with the severity of dyspnea. Methods: This was a cross-sectional study involving adult patients with HRCT-confirmed bronchiectasis, categorized according to the severity of dyspnea (as being mildly or severely symptomatic, on the basis of the modified Medical Research Cou...
Exploratory analysis of requests for authorization to dispense high-cost medica...
Carvalho-Pinto,Regina Maria; Silva,Ingredy Tavares da; Navacchia,Lucas Yoshio Kido; Granja,Flavia Munhos; Marques,Gustavo GarciaABSTRACT Objective: A resolution passed by the government of the Brazilian state of São Paulo established a protocol for requesting free COPD medications, including tiotropium bromide, creating regional authorization centers to evaluate and approve such requests, given the high cost of those medications. Our objective was to analyze the requests received by an authorization center that serves cities in the grea...
Efeito agudo do salbutamol no sistema cardiovascular durante o exercício físico...
Melo,Jaqueline Ribas de; Feitoza,Maiane da Silva; Cucato,Gabriel Grizzo; Medeiros,Wladimir Musetti; Stelmach,Rafael; Cukier,AlbertoRESUMO Salbutamol é um β2-agonista de curta duração frequentemente utilizado em pacientes com asma para prevenir os sintomas durante ou após exercício físico. Alterações hemodinâmicas em repouso estão bem descritas. Contudo são escassos os dados sobre os efeitos na frequência cardíaca (FC) e pressão arterial (PA) durante o exercício e na fase de recuperação em pacientes com asma moderada ou grave. Foi realizado...
Spirometry in patients screened for coronary artery disease: is it useful?
Fernandes,Frederico Leon Arrabal; Carvalho-Pinto,Regina Maria; Stelmach,Rafael; Salge,João Marcos; Rochitte,Carlos EduardoABSTRACT Objective: To determine the prevalence of spirometric abnormalities in patients screened for coronary artery disease (CAD) and the risk factors for lung function impairment. Methods: Patients referred for cardiac CT underwent spirometry and were subsequently divided into two groups, namely normal lung function and abnormal lung function. The prevalence of spirometric abnormalities was calculated for th...
The patient profile of individuals with Alpha-1 antitrypsine gene mutations at ...
Felisbino,Manuela Brisot; Fernandes,Frederico Leon Arrabal; Nucci,Maria Cecília Nieves Maiorano de; Pinto,Regina Maria de Carvalho; Pizzichini,EmilioABSTRACT Objective: The clinical, functional, radiological and genotypic descriptions of patients with an alpha-1 antitrypsin (A1AT) gene mutation in a referral center for COPD in Brazil. Methods: A cross-sectional study of patients with an A1AT gene mutation compatible with deficiency. We evaluated the A1AT dosage and genotypic, demographic, clinical, tomographic, and functional characteristics of these patien...
Effect of salbutamol on the cardiovascular response in healthy subjects at rest...
Feitoza,Maiane da Silva; Melo,Jaqueline Ribas de; Medeiros,Wladimir Musetti; Cucato,Gabriel Grizzo; Stelmach,Rafael; Cukier,AlbertoABSTRACT Aim To evaluate the effect of the short-acting beta agonists (SABAs) salbutamol on cardiovascular response rest, exercise and recovery phase. Methods This study was conducted as a randomized, double-blind, placebo controlled, crossover study in 15 healthy adults, with a mean age of 30.2±6.6 years. Participants underwent a maximal effort test on two non-consecutive days with 400 mcg of salbutamol or pla...
Recommendations for the pharmacological treatment of COPD: questions and answers
Fernandes,Frederico Leon Arrabal; Cukier,Alberto; Camelier,Aquiles Assunção; Fritscher,Carlos Cezar; Costa,Cláudia Henrique daABSTRACT The treatment of COPD has become increasingly effective. Measures that range from behavioral changes, reduction in exposure to risk factors, education about the disease and its course, rehabilitation, oxygen therapy, management of comorbidities, and surgical and pharmacological treatments to end-of-life care allow health professionals to provide a personalized and effective therapy. The pharmacological...
A workshop on asthma management programs and centers in Brazil: reviewing and e...
Stelmach,Rafael; Neto,Alcindo Cerci; Fonseca,Ana Cristina de Carvalho Fernandez; Ponte,Eduardo Vieira; Alves,Gerardo; Araujo-Costa,Ildely NiediaObjective: To report the results of a workshop regarding asthma management programs and centers (AMPCs) in Brazil, so that they can be used as a tool for the improvement and advancement of current and future AMPCs. Methods: The workshop consisted of five presentations and the corresponding group discussions. The working groups discussed the following themes: implementation of asthma management strategies; human...