5 documents found, page 1 of 1
Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis
Cardoso, A; Martins, AC; Maceiras, AR; Liu, W; Castro, I; Castro, AG; Bandeira, A; Di Santo, JP; Cumano, A; Li, Y; Vieira, P; Saraiva, MIn emergency myelopoiesis (EM), expansion of the myeloid progenitor compartment and increased myeloid cell production are observed and often mediated by the pro-inflammatory cytokine interferon gamma (IFN-γ). Interleukin-10 (IL-10) inhibits IFN-γ secretion, but paradoxically, its therapeutic administration to humans causes hematologic changes similar to those observed in EM. In this work, we use different in vi...
Hematopoiesis: A Layered Organization Across Chordate Species
Elsaid, R; Soares-da-Silva, F; Peixoto, M; Amiri, D; Mackowski, N; Pereira, P; Bandeira, A; Cumano, AThe identification of distinct waves of progenitors during development, each corresponding to a specific time, space, and function, provided the basis for the concept of a “layered” organization in development. The concept of a layered hematopoiesis was established by classical embryology studies in birds and amphibians. Recent progress in generating reliable lineage tracing models together with transcriptional...
Crosstalk Between the Hepatic and Hematopoietic Systems During Embryonic Develo...
Soares-da-Silva, F; Peixoto, M; Cumano, A; Pinto-do-Ó, PHematopoietic stem cells (HSCs) generated during embryonic development are able to maintain hematopoiesis for the lifetime, producing all mature blood lineages. HSC transplantation is a widely used cell therapy intervention in the treatment of hematologic, autoimmune and genetic disorders. Its use, however, is hampered by the inability to expand HSCs ex vivo, urging for a better understanding of the mechanisms ...
Mouse HSA+ immature cardiomyocytes persist in the adult heart and expand after ...
Valente, M; Resende, TP; Nascimento, DS; Burlen-Defranoux, O; Soares-da-Silva, F; Dupont, B; Cumano, A; Pinto-do-Ó, PThe assessment of the regenerative capacity of the heart has been compromised by the lack of surface signatures to characterize cardiomyocytes (CMs). Here, combined multi-parametric surface marker analysis with single-cell transcriptional profiling and in vivo transplantation identify the main mouse fetal cardiac populations and their progenitors (PRGs). We found that CMs at different stages of differentiation ...
The Dynamics of Interleukin-10-afforded protection during dextran sulfate sodiu...
Cardoso, A; Castro, A; Martins, AC; Carriche, GM; Murigneux, V; Castro, I; Cumano, A; Vieira, P; Saraiva, MInflammatory bowel disease encompasses a group of chronic-inflammatory conditions of the colon and small intestine. These conditions are characterized by exacerbated inflammation of the organ that greatly affects the quality of life of patients. Molecular mechanisms counteracting this hyperinflammatory status of the gut offer strategies for therapeutic intervention. Among these regulatory molecules is the anti-...