21 documents found, page 1 of 3
Avulsive Achilles Tendon Rupture in a Patient With Alkaptonuria: A Case Report
Fabião, L; França, G; Cunha, A; S. Pereira, B; Esteves, NAlkaptonuria is a rare autosomal recessive disease caused by a mutation in the homogentisate 1,2-dioxygenase (HGO) gene, leading to the accumulation of homogentisic acid (HGA). HGA polymerizes to form a black pigment that accumulates in connective tissue and joints (ochronosis), causing their destruction. In this work, we report a case of Achilles tendon rupture in a patient with a prior diagnosis of alkaptonur...
Dating recent tidal marsh sediments using windborne giant particles of green pe...
Moreno, J; Leorri, E; Fatela, F; Freitas, MC; Moreno, F; Mirão, J; Dias, L; Leira, M; Masqué, P; Russo, A; Cunha, A; Inácio, M; Blake, WHCoastal systems are especially vulnerable to human activities resulting from a range of direct physical modifications of the ecosystems to the biological, chemical, and physical impacts of pollutants. For the most recent decades, these modifications can be accurately tracked by industrial development indicators, providing an exceptional record of historical changes. In return, when such changes are identified i...
Sharing biomedical data: Strengthening ai development in healthcare
Pereira, T; Morgado, J; Silva, F; Pelter, MM; Dias, VR; Barros, R; Freitas, C; Negrão, E; Lima, BF; Silva, MC; Madureira, AJ; Ramos, I; Hespanhol, VArtificial intelligence (AI)-based solutions have revolutionized our world, using extensive datasets and computational resources to create automatic tools for complex tasks that, until now, have been performed by humans. Massive data is a fundamental aspect of the most powerful AI-based algorithms. However, for AI-based healthcare solutions, there are several socioeconomic, technical/infrastructural, and most i...
The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer
Freitas, C; Sousa, C; Machado, F; Serino, M; Santos, V; Martins, N; Teixeira, A; Cunha, A; Pereira, T; Oliveira, HP; Costa, JL; Hespanhol, VLiquid biopsy is an emerging technology with a potential role in the screening and early detection of lung cancer. Several liquid biopsy-derived biomarkers have been identified and are currently under ongoing investigation. In this article, we review the available data on the use of circulating biomarkers for the early detection of lung cancer, focusing on the circulating tumor cells, circulating cell-free DNA,...
EGFR Assessment in Lung Cancer CT Images: Analysis of Local and Holistic Region...
Silva, F; Pereira, T; Morgado, J; Frade, J; Mendes, J; Freitas, C; Negrao, E; Lima, BF; Silva, M; Madureira, AJ; Ramos, I; Hespanhol, V; Costa, JLStatistics have demonstrated that one of the main factors responsible for the high mortality rate related to lung cancer is the late diagnosis. Precision medicine practices have shown advances in the individualized treatment according to the genetic profile of each patient, providing better control on cancer response. Medical imaging offers valuable information with an extensive perspective of the cancer, openi...
Use of antibiotics during pregnancy is associated to infection in children at f...
Cunha, A; Santos, AC; Medronho, R; Barros, HAim To assess the association between taking antibiotics in pregnancy and the occurrence of infections in children at four years of age. Methods We studied children who participated in the follow-up of the birth cohort Generation XXI, Porto-Portugal, at the age of four years. We evaluated the associations between the use of antibiotics by the mother at any time in pregnancy with the occurrence of infections. Da...
Machine learning and feature selection methods for egfr mutation status predict...
Morgado, J; Pereira, T; Silva, F; Freitas, C; Negrão, E; Lima, BF; Silva, MC; Madureira, AJ; Ramos, I; Hespanhol, V; Costa, JL; Cunha, A; Oliveira, HPThe evolution of personalized medicine has changed the therapeutic strategy from classical chemotherapy and radiotherapy to a genetic modification targeted therapy, and although biopsy is the traditional method to genetically characterize lung cancer tumor, it is an invasive and painful procedure for the patient. Nodule image features extracted from computed tomography (CT) scans have been used to create machin...
Cognivitra, a digital solution to support dual-task rehabilitation training
Quintas, J; Pais, J; Martins, AI; Santos, H; Neves, L; Sousa, S; Benhsain, D; Dierick, F; Callén, A; Cunha, A; Rocha, NP; Cruz, VTThis article focuses on an eHealth application, CogniViTra, to support cognitive and physical training (i.e., dual-task training), which can be done at home with supervision of a health care provider. CogniViTra was designed and implemented to take advantage of an existing Platform of Services supporting a Cognitive Health Ecosystem and comprises several components, including the CogniViTra Box (i.e., the patie...
Comprehensive perspective for lung cancer characterisation based on AI solution...
Pereira, T; Freitas, C; Costa, JL; Morgado, J; Silva, F; Negrão, E; Lima, BF; Silva, MC; Madureira, AJ; Ramos, I; Hespanhol, V; Cunha, A; Oliveira, HPLung cancer is still the leading cause of cancer death in the world. For this reason, novel approaches for early and more accurate diagnosis are needed. Computer-aided decision (CAD) can be an interesting option for a noninvasive tumour characterisation based on thoracic computed tomography (CT) image analysis. Until now, radiomics have been focused on tumour features analysis, and have not considered the infor...
Pre-training autoencoder for lung nodule malignancy assessment using CT images
Silva, F; Pereira, T; Frade, J; Mendes, J; Freitas, C; Hespanhol, V; Costa, JL; Cunha, A; Oliveira, HPLung cancer late diagnosis has a large impact on the mortality rate numbers, leading to a very low five-year survival rate of 5%. This issue emphasises the importance of developing systems to support a diagnostic at earlier stages. Clinicians use Computed Tomography (CT) scans to assess the nodules and the likelihood of malignancy. Automatic solutions can help to make a faster and more accurate diagnosis, which...