3 documents found, page 1 of 1
Shape-versatile fixed cellular materials for multiple target immunomodulation
Sousa, Ana Rita; Cunha, Ana F.; Santos-Coquillat, Ana; Estrada, Beatriz Hernaez; Spiller, Kara L.; Barão, Marta; Rodrigues, Artur Filipe; Simões, SusanaTherapeutic cells are usually administered as living agents, despite the risks of undesired cell migration and acquisition of unpredictable phenotypes. Additionally, most cell-based therapies rely on the administration of single cells, often associated with rapid in vivo clearance. Three-dimensional cellular materials may be useful to prolong the effect of cellular therapies and offer the possibility of creatin...
Tricalcium phosphate doped with Mg2+ and combinations of Mn2+, Zn2+ and Fe3+: A...
Macedo, Duarte F.; Cunha, Ana F.; Mano, João F.; Oliveira, Mariana B.; Silva, Abílio P.Bioactive ceramics such as tricalcium phosphate (TCP) doped with metal ions are often used to replace natural bone in orthopedic and dental function, both in structural and coating applications. Although the addition of different ions to TCP has been correlated with improved mechanical performance, as well as pro-osteogenic and osteointegrative biological activities, the effect of combining different ions in si...
Cell response in free-packed granular systems
Cunha, Ana F.; Matias, André F. V.; Dias, Cristóvão S.; Oliveira, Mariana B.; Araújo, Nuno A. M.; Mano, João F.The study of the interactions of living adherent cells with mechanically stable (visco)elastic materials enables understanding and exploitation of physiological phenomena mediated by cell-extracellular communication. Insights into the interaction of cells and surrounding objects with different stability patterns upon cell contact might unveil biological responses to engineer innovative applications. Here, we hy...