4 documents found, page 1 of 1
Frequency of CDH1, CTNNA1 and CTNND1 germline variants in families with diffuse...
Guerra, Joana; Pinto, Carla; Pinto, Pedro; Pinheiro, Manuela; Santos, Catarina; Peixoto, Ana; Escudeiro, Carla; Barbosa, Ana; Porto, MiguelHereditary diffuse gastric cancer (HDGC) is caused by germline pathogenic variants in the CDH1 and CTNNA1 genes and is characterized by a high prevalence of diffuse gastric cancer and lobular breast cancer. We aimed to evaluate the contribution of CTNNA1 and CTNND1 germline variants to HDGC, as well as to compare the frequencies of CDH1 and CTNNA1 (and eventually CTNND1) germline variants between patients with ...
Not Always a Thymoma – About a Mediastinal Cavernous Hemangioma
Pinto, Paula; Castro, João; Leite, Filipe; Cunha, Ana Luísa; Lopes, Sara; Paupério, GonçaloA mediastinal cavernous hemangioma is difficult to distinguish from other types of mediastinal tumours. They are usually asymptomatic and incidentally discovered in an imaging study but can present with compressive symptoms or by infiltration of adjacent structures. A 64-year-old woman with a prior history of triple negative invasive carcinoma of the breast, under surveillance was referred after a Chest CT-scan...
Idiopathic Pyoderma Gangrenosum Treated with Adalimumab: A Case of Success
Gomes, Nuno; Amoedo, Patrícia; Cunha, Ana Luísa; Azevedo, Filomena; Magina, Sofia
Cytogenetic alterations induced by radiation in amniocytes
Pires, Ana Salomé; Pinto, Marta; Silveira, Paula; Brito, Ana Filipa; Fonseca, Sérgio; Castro, Ismael; Dias, Sílvia; Cunha, Ana Luísa; Ferreira, MarisaWhen cells are submitted to ionizing radiation, they respond with physico-chemical phenomena like ionization/excitation of atoms and energy distribution over the cells, chemical reactions with formation of free radicals and rupture of chemical bonds and biological alterations leading to specific changes of cellular functions with decrease of cellular activity. Therefore, both tissues and organs are affecte...