2 documents found, page 1 of 1
Evidence for lack of direct causality between pain and affective disturbances i...
Guimarães, Marco Rafael Machado; Soares, Ana R.; Cunha, Ana M.; Esteves, Madalena; Borges, Sónia; Magalhães, Ricardo José SilvaChronic pain is frequently accompanied by the manifestation of emotional disturbances and cognitive deficits. While a causality relation between pain and emotional/cognitive disturbances is generally assumed, several observations suggest a temporal dissociation and independent mechanisms. We therefore studied Sprague-Dawley rats that presented a natural resistance to pain manifestation in a neuropathy model (sp...
Pawedness trait test (PaTRaT) : a new paradigm to evaluate paw preference and d...
Cunha, Ana M.; Esteves, Madalena Curva; Neves, Sofia Pereira; Borges, Sónia Maria de Sousa; Guimarães, Marco Rafael Machado; Sousa, NunoIn rodents, dexterity is commonly analyzed in preference paradigms in which animals are given the chance to use either the left or the right front paws to manipulate food. However, paw preference and dexterity at population and individual levels are controversial as results are incongruent across paradigms. We have therefore developed a semi-quantitative method-the pawdeness trait test (PaTRaT)-to evaluate paw ...