4 documents found, page 1 of 1
Exploring the potential of dichloroacetate in targeting oral cancer metabolism
Teixeira, João; Cunha, Andrea; A. Silva, Patrícia M.Background: Oral cancer represents a significant global health burden, and its incidence is steadily rising [1]. A hallmark of cancer is metabolic reprogramming - most notably, a shift toward aerobic glycolysis, commonly known as the Warburg effect. This altered metabolic phenotype supports rapid proliferation, enhances survival under hypoxic conditions, and contributes to resistance to conventional therapies. ...
Evaluation of antitumor activity of xanthones conjugated with amino acids
Barbosa, Flávia; Araújo, Joana; F. Gonçalves , Virgínia M.; Palmeira, Andreia; Cunha, Andrea; A. Silva, Patrícia M.; Fernandes, Carla; Pinto, MadalenaBackground: Cancer is a complex disease characterized by several alterations that confer on the cells, the capacity to proliferate uncontrollably and to resist cellular death. Multiresistance to conventional chemotherapy drugs is often the cause of treatment failure; thus, the search for natural products or their derivatives with therapeutic action is essential. Chiral derivatives of xanthones (CDXs) have ...
Unravelling the Warburg effect: glycolytic inhibitors as promising agents in ca...
Cunha, Andrea; Silva, Patrícia; Rocha, Ana Catarina; Queirós, OdíliaThe study of metabolic changes in cancer cells and their influence on tumor progression is still a challenge in oncobiology. Cancer cells are characterized by their high rates of glycolysis, even in the presence of oxygen, a phenomenon described as the Warburg effect. The increased glycolytic flux induces extracellular space acidification and boosts the more aggressive characteristics of cancer cells. Since mon...
Ensaios in vitro de avaliação do efeito antitumoral de inibidores glicolíticos
Cunha, Andrea; Rocha, Ana Catarina; Silva, Daniela; Barbosa, Flávia; Sarmento, Bruno; Queirós, OdíliaA quimioterapia é particularmente tóxica para as células tumorais; porém, não é específica, sendo responsável por importantes efeitos adversos associados ao tratamento. O "Efeito Warburg" é uma característica do cancro, que consiste numa alteração metabólica na produção de energia da fosforilação oxidativa para a glicólise, mesmo na presença de O2. A ativação contínua da glicólise conduz a um rápido aumento de ...