32 documents found, page 1 of 4

A functional polymorphism in IL-36β modulates macrophage antifungal effector fu...

Background: Genetic predisposition plays a major role in the development of invasive pulmonary aspergillosis (IPA). The risk and course of IPA vary significantly among patients, yet continuously new genetic mechanisms that influence individual antifungal immune responses are being discovered. While genetic variability in interleukin (IL)-1 family cytokines is recognized as an important cause of disease suscepti...

Interferon gamma rebalances immunopathological signatures in chronic granulomat...

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent life-threatening infections and hyperinflammatory complications. It is caused by mutations in the reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex and the consequent loss of reactive oxygen species (ROS) production. Recombinant human interferon gamma (rIFN-γ) prophylaxis reduces the risk of se...

Opinionated texts in social media: A proposal for evaluative judgement methodology

The paper reports on a pilot study devoted to the analysis of opinions expressed by Facebook discussants related to the immigration crisis in Europe. Opinions were conceptualised as the subjective expression of evaluation. The data were investigated in line with an original, tripartite typology consisting of 46 criteria of evaluative language coming from distinct scholarly traditions: media studies, linguistics...

Erythrocyte-derived liposomes for the treatment of inflammatory diseases

Effective and safe therapies to counteract persistent inflammation are necessary. We developed erythrocyte-derived liposomes (EDLs) with intrinsic anti-inflammatory activity. The EDLs were prepared using lipids extracted from erythrocyte membranes, which are rich in omega-3 fatty acids with several health benefits. Diclofenac, a widely used anti-inflammatory drug, was incorporated into EDLs in relevant therapeu...

Bisphenol a and cardiometabolic risk in adolescents: data from the generation X...

Literature review and discussion on collaborative decision making approaches in...

Nowadays, companies are faced with an increasingly higher level of competition while frying to adapt to the exigencies imposed by the Industry 4.0, regarding its usually referred dimensions and pillars, among which one that although is not so often referred is also expressing an increasing visibility and importance, related to collaboration, and more specifically to collaborative decision making and co-working....

Host immune genetic variations influence the risk of developing acute myeloid l...

The purpose of this study was to conduct a two-stage case control association study including 654 acute myeloid leukaemia (AML) patients and 3477 controls ascertained through the NuCLEAR consortium to evaluate the effect of 27 immune-related single nucleotide polymorphisms (SNPs) on AML risk. In a pooled analysis of cohort studies, we found that carriers of the IL13rs1295686A/A genotype had an increased risk of...

High-resolution melting assay for genotyping variants of the CYP2C19 enzyme and...

Voriconazole is a triazole antifungal agent recommended as primary treatment for invasive aspergillosis, as well as some other mold infections. However, it presents some pharmacokinetic singularities that lead to a great variability intra- and interindividually, nonlinear pharmacokinetics, and a narrow therapeutic range. Most experts have recommended tracing the levels of voriconazole in patients when receiving...

Interleukin-6 neutralization by antibodies immobilized at the surface of polyme...

Arthritic diseases are disabling conditions affecting millions of patients worldwide. Pro-inflammatory cytokines, particularly interleukin-6 (IL-6), plays a crucial role in inflammation and cartilage destruction. Although the beneficial effects of antibody therapy, its efficacy is limited. Therefore, this work proposes the immobilization of antibodies at the surface of biodegradable polymeric nanoparticles (NPs...

Advanced treatment for arthritic diseases based on the capture and inactivation...

Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, are associated with synovium inflammation (synovitis). Several pro-inflammatory cytokines, especially tumor necrosis factor-α (TNFα) and interleukins (IL), are important mediators of inflammation and articular cartilage destruction, supporting a potential possibility of anticytokine therapy in these diseases. IL-6 is one of the key regulators ...