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Rotavirus alphagastroenteritidis: circulating strains after the introduction of...

Vita, Dikudila G.; Santiso-Bellón, Cristina; Lemos, Manuel; Neto, Zoraima; Fortes-Gabriel, Elsa; Brito, Miguel; Sebastião, Cruz S.

Rotavirus alphagastroenteritidis (R. alphagastroenteritidis) remains the leading cause of pediatric diarrhea. Although Angola introduced Rotarix®, the human monovalent R. alphagastroenteritidis vaccine since 2014 as part of its routine childhood immunization program, no follow-up study has been conducted. This study aimed to evaluate the distribution of R. alphagastroenteritidis genotypes among children under f...


HEPATITE DELTA

Branco, Cristina; Alves, Carolina; Cunha, Celso

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HIV-2 integrase polymorphisms and longitudinal genotypic analysis of HIV-2 infe...

Cavaco-Silva, Joana; Abecasis, Ana; Miranda, Ana Cláudia; Poças, José; Narciso, Jorge; Águas, Maria João; Maltez, Fernando; Almeida, Isabel


The heterogeneous ribonuclear protein C interacts with the hepatitis delta viru...

Casaca, Ana; Fardilha, Margarida; Silva, Edgar da Cruz e; Cunha, Celso

Background: Hepatitis delta virus (HDV) is considered to be a satellite virus of the Hepatitis B virus. The genome consists of a 1679 nt ssRNA molecule in which a single ORF was identified. This ORF codes for a unique protein, the Delta antigen (HDAg). During transcription, two forms, small (S-HDAg; p24) and large (L-HDAg; p27) of this antigen are derived as a result of an editing mechanism catalyzed by cellula...


In vivo interaction of the hepatitis delta virus small antigen with the ELAV-li...

Casaca, Ana; Fardilha, Margarida; Silva, Edgar da Cruz e; Cunha, Celso

The small and large delta antigens (S-HDAg and L-HDAg, respectively) represent two forms of the only protein encoded by the hepatitis delta virus (HDV) RNA genome. Consequently, HDV relies, at a large extent, on the host cell machinery for replication and transcription. Until now, only a limited number of cellular proteins were identified as S-HDAg or L-HDAg partners being involved in the modulation of the viru...


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