105 documents found, page 1 of 11

Apresentação

Profiling bacteria in the lungs of patients with severe influenza versus COVID-...

Rationale: The influence of the lung bacterial microbiome, including potential pathogens, in patients with influenza-associated pulmonary aspergillosis (IAPA) or coronavirus disease (COVID-19)-associated pulmonary aspergillosis (CAPA) has yet to be explored. Objectives: To explore the composition of the lung bacterial microbiome and its association with viral and fungal infection, immunity, and outcome in sever...

Metabolic regulation of the host-fungus interaction: from biological principles...

Fungal infections present a significant global public health concern, impacting over 1 billion individuals worldwide and resulting in more than 3 million deaths annually. Despite considerable progress in recent years, the management of fungal infections remains challenging. The limited development of novel diagnostic and therapeutic approaches is largely attributed to our incomplete understanding of the pathoge...

Multicentric Study on the Clinical Mycology Capacity and Access to Antifungal T...

The success of the clinical management of invasive fungal diseases (IFD) is highly dependent on suitable tools for timely and accurate diagnosis for effective treatment. An in-depth analysis of the ability of European institutions to promptly and accurately diagnose IFD was previously conducted to identify limitations and aspects to improve. Here, we evaluated and discussed the specific case of Portugal, for wh...

Apresentação [Revolução de Abril: cinquenta anos depois]

Apresentação [dossiê temático Educação e Democracia: histórias e memórias dos ú...

A Guarda medieval eclesiástica

Discrimen veri ac falsi: ainda e sempre o caminho da Diplomática

The present paper seeks to reflect on the paths that have been taken and those that are being faced by Diplomatics in the first quarter of the 21st century. The aim of this science remains the same as when Mabillon published the De Re Diplomatica - to verify the authenticity of documental sources - and it has been accepted for some time now that it is open to new periods and new geographies for the analysis of ...

Comprehensive assessment of environmental fungus-reactive T cells response in h...

Hypersensitivity pneumonitis (HP) is an interstitial lung disease that results in parenchymal and small airways inflammation and culminates in breathlessness, negatively impacting patient’s quality of life and survival. HP is initiated by an exaggerated immune response triggered by the inhalation of a variety of environmental antigens. The identification of the triggering antigen is a cornerstone of the diagnos...

Apresentação