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Tumor-Infiltrating T Cells in Skin Basal Cell Carcinomas and Squamous Cell Carc...

Cunha, D; Neves, M; Silva, D; Silvestre, AR; Nunes, PB; Arrobas, F; Ribot, JC; Ferreira, F; Moita, LF; Soares-de-Almeida, L; Silva, JM; Filipe, P

Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are high-incidence, non-melanoma skin cancers (NMSCs). The success of immune-targeted therapies in advanced NMSCs led us to anticipate that NMSCs harbored significant populations of tumor-infiltrating lymphocytes with potential anti-tumor activity. The main aim of this study was to characterize T cells infiltrating NMSCs. Flow cytometry and immuno...

Date: 2024   |   Origin: Saúde - CUF

PERFORMANCE OF THE MEDICATION ADHERENCE UNIVERSAL QUESTIONNAIRE (MAUQ) IN PATIE...

Fortunato, AR; Araujo, A; Barbosa, C; Cunha, D; Costa, J; Silva, M; Ferreira, S; Cabral, AC; Branco, MC; Figueiredo, IV; Fernandez-Llimos, F


Performance of the Medication Adherence Universal Questionnaire (MAUQ) in patie...

Fortunato, AR; Araújo, A; Barbosa, C; Cunha, D; Costa, J; Silva, M; Ferreira, S; Cabral, AC; Castel Branco, M; Figueiredo, IV; Fernandez Llimos, F


Pulmonary hyalinizing granuloma: Atypical presentation

Cunha, D; Melo, N; Guimarães, S; Moura, CS; Pereira, JM; Morais, A


Co-morbidities and sleep apnoea severity. A study in a cohort of Portuguese pat...

Silva, L; Cunha, D; Lopes, J; Ramalheira, J; Freire, M; Novío, S; Núñez, MJ; Mendonça, D; Martins-Da-Silva, A

Introduction. Obstructive sleep apnoea syndrome (OSAS) is frequently associated to other morbid conditions that act as risk factors influencing OSAS morbidity and mortality. Aim. To analyse the presence of co-morbidities in OSAS patients, recruited from a sleep outpatient clinic in Northern Portugal, stratified as a function of OSAS severity. Patients and methods. A cohort of 319 sleep-disordered patients was a...


Usefulness of genetic characterization of narcolepsy and hypersomnia on phenoty...

Martins-da-Silva, A; Lopes, J; Ramalheira, J; Carvalho, C; Cunha, D; Pinho-Costa, P; Silva, B

[ENG] Introduction. The determination of human leukocyte antigen (HLA) class II genotype is widely used to confirm the diagnosis of narcolepsy with or without cataplexy. The HLA genotyping is reliable, easy to perform and reassures the clinician. It is also less invasive than other methodologies and is in accordance with the autoimmune hypothesis for the origin of narcolepsy. Aim. To assess the usefulness of ge...



Dermoscopy in Merkel Cell Carcinoma: a Case Report

Laureano, A; Cunha, D; Fernandes, C; Cardoso, J

Merkel cell carcinoma (MCC) is a rare malignant and primary neuroendocrine carcinoma with several known risk factors. Early diagnosis and aggressive treatment are critical. We report the case of an 82-year old woman with a Merkel cell carcinoma on the face. Clinical and histopathological features are presented. In addition, dermoscopic features and the differential diagnosis of this rare tumor are discussed. Al...


Consensus document on coding of cardiac magnetic resonance examinations in Port...

Ferreira, MA; Almeida, AG; Oliveira, L; Bettencourt, N; Marques, H; Matos, P; Abecasis, J; Abreu, J; Alpendurada, F; Botelho, A; Campos, P; Castela, S

One of the obstacles to more frequent and appropriate use of cardiac magnetic resonance (CMR) in Portugal has been the lack of specific codes that accurately describe these examinations as they are currently performed. In this consensus document, recommendations are made for updating and standardizing CMR codes in Portugal. Guidance on which techniques and codes should be used in the most common clinical scenar...


Infeção Cutânea e Pulmonar por Mycobacterium Africanum

Francisco, T; Cunha, D; Vieira, R; Afonso, A; Brito, MJ

A tuberculose cutânea é uma doença incomum, constituindo 1,5% de todas as formas de tuberculose. Na doença pulmonar e cutânea, as infeções causadas por Mycobacterium africanum e Mycobacterium tuberculosis podem ser clinicamente indistinguíveis. Um rapaz de 6 anos da Guiné-Bissau foi hospitalizado devido a uma úlcera pré-auricular direita com evolução de dois anos e linfadenopatia regional. O teste tuberculínico...


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