3 documents found, page 1 of 1
The CgHaa1-regulon mediates response and tolerance to acetic acid stress in the...
Bernardo, Ruben T.; Cunha, Diana V.; Wang, Can; Pereira, L. P.; Silva, Sónia Carina; Salazar, Sara B.; Schröder, Markus S.; Okamoto, MichiyoTo thrive in the acidic vaginal tract C. glabrata has to cope with high concentrations of acetic acid. The mechanisms underlying C. glabrata tolerance to acetic acid at low pH remain largely uncharacterized. In this work it is demonstrated the essential role of the CgHaa1 transcription factor (encoded by ORF CAGL0L09339g) in the response and tolerance of C. glabrata to acetic acid. Transcriptomic analysis showe...
Genetic adaptive mechanisms mediating response and tolerance to acetic acid str...
Bernardo, Ruben T.; Cunha, Diana V.; Wang, Can; Chibana, Hiroji; Silva, Sónia Carina; Sá-Correia, Isabel; Azeredo, Joana; Butler, GeraldineC. glabrata is a commensal found in the human genitourinary tract but under certain conditions this harmless colonization evolves to a mucosal infection and, in more serious cases, to disseminated mycosis. To thrive in the acidic vaginal tract C. glabrata has to cope with the presence of a competing commensal microbiota known to restrain the overgrowth of pathogens through the production of acetic and lactic ac...
The CgHaa1-dependent pathway mediates Candida glabrata response and tolerance t...
Bernardo, Ruben; Silva, Sónia Carina; Cunha, Diana V.; Pereira, Leonel; Wang, Can; Correia, Isabel Sá; Chibana, Hiroji; Butler, GeraldineTo successfully colonize the vaginal tract Candida glabrata has to cope with various stresses including the presence of acetic acid at a low pH that is produced by the bacteria that co-colonize this niche. The genes/pathways involved in C. glabrata tolerance and response to acetic acid are largely unknown, although these are a highly interesting set of novel targets to control vaginal infections caused by this ...