4 documents found, page 1 of 1

UBUNTU: The challenge of promoting socio-emotional skills in the school context

The relevance of social-emotional skills in education, as an essential condition to face the multiple challenges of a multidisciplinary and constantly changing society, has long been known. However, the pandemic and its consequences, namely in terms of mental health, have highlighted what the contributions of psychology and neurosciences had underlined nearly two decades ago. The Ubuntu Schools program, by the ...

Characterization of cisplatin-induced cell death in Saccharomyces cerevisia

Cisplatin is a highly effective chemotherapeutic drug used in the treatment of several cancers, such as testicular, ovarian, cervical, head and neck and small-cell lung cancer. It is a DNA-damaging agent that induces apoptosis of rapidly proliferating cells, an important factor underlying its therapeutic efficacy. Unfortunately, despite high cure rates, its curative potential is often impaired when cells develo...

Characterization of cisplatin-induced cell death in S. cerevisiae

Yeast as a model system to study mechanisms regulating cisplatin sensitivity an...

Cisplatin is a highly effective chemotherapeutic drug used in the treatment of several tumors. It is a DNA-damaging agent that induces apoptosis of rapidly proliferating cells, an important factor underlying its therapeutic efficacy. Unfortunately, cellular resistance occurs often. A large fraction of tumor cells harbor mutations in p53, contributing to defects in apoptotic pathways and drug resistance. However...