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Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in ...

Sereno, José; Parada, Belmiro; Reis, Flávio; Cunha, Fernanda X; Teixeira-Lemos, Edite; Garrido, Patrícia; Pinto, Rui; Rocha-Pereira, Petronila

To evaluate the effect of a cyclooxygenase 2 inhibitor, celecoxib (CEL), on bladder cancer inhibition in a rat model, when used as preventive versus as curative treatment. The study comprised 52 male Wistar rats, divided in 5 groups, during a 20-week protocol: control: vehicle, carcinogen: 0.05% of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), CEL: 10  mg/kg/day of the selective COX-2 inhibitor Celebrex, preven...

Date: 2010   |   Origin: Estudo Geral - Universidade de Coimbra
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