16 documents found, page 1 of 2
Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blo...
Silva, Camila Meirelles S.; Wanderley, Carlos Wagner S.; Veras, Flavio P.; Sonego, Fabiane; Nascimento, Daniele C.; Gonçalves, Augusto V.Made available in DSpace on 2022-04-29T08:46:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-23; Multiple organ dysfunction is the most severe outcome of sepsis progression and is highly correlated with a worse prognosis. Excessive neutrophil extracellular traps (NETs) are critical players in the development of organ failure during sepsis. Therefore, interventions targeting NET release would likely...
Neural Infection by Oropouche Virus in Adult Human Brain Slices Induces an Infl...
Almeida, Glaucia M.; Souza, Juliano P.; Mendes, Niele D.; Pontelli, Marjorie C.; Pinheiro, Nathalia R.; Nogueira, Giovanna O.; Cardoso, Ricardo S.Made available in DSpace on 2022-04-29T08:46:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-23; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo; Fundação de Amp...
Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study...
Ventura Fernandes, Bianca H.; Feitosa, Natália Martins; Barbosa, Ana Paula; Bomfim, Camila Gasque; Garnique, Anali M.B.; Rosa, Ivana F. [UNESP]Made available in DSpace on 2022-04-29T08:46:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-20; Ministério da Ciência, Tecnologia e Inovação; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Despite the significant increase in the generation of SARS-CoV-2 contaminated domestic and hospital wastewater, little is kno...
The carotid body detects circulating tumor necrosis factor-alpha to activate a ...
Katayama, Pedro L. [UNESP]; Leirão, Isabela P. [UNESP]; Kanashiro, Alexandre; Luiz, João P.M.; Cunha, Fernando Q.; Navegantes, Luiz C.C.Made available in DSpace on 2022-04-29T08:46:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-05-01; Booz Allen Foundation; Recent evidence has suggested that the carotid bodies might act as immunological sensors, detecting pro-inflammatory mediators and signalling to the central nervous system, which, in turn, orchestrates autonomic responses. Here, we confirmed that the TNF-α receptor type I is expre...
Regulation of angiotensin II receptors levels during rat induced pulpitis
Souza, Pedro P.C.; Fukada, Sandra Y.; Cunha, Fernando Q.; Costa, Carlos A.S.; Costa-Neto, Claudio M.Made available in DSpace on 2022-04-29T08:43:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-04-05; A change in the microcirculatory hemodynamic is one of the most important events in inflammation. In the dental pulp, which is a connective tissue surrounded by a mineralized dentine substrate, disturbance in the blood flow as well as plasma extravasation may increase the pulp pressure and cause local i...
Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis
Colón, David F.; Wanderley, Carlos W.; Franchin, Marcelo; Silva, Camila M.; Hiroki, Carlos H.; Castanheira, Fernanda V. S.; Donate, Paula B.Background: Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown. Methods: Infant (2 weeks old) and adult (6 weeks old) mice were submitted to sepsis by intraperitoneal (i.p.) injection of bacteria suspension or lipopolysaccharide (LPS). Neutrophil infiltration, bacteremia, ...
Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice P...
Santos, Nilton B Dos; Franco, Roseane D.; Camarini, Rosana; Munhoz, Carolina D.; Eichler, Rosangela A S; Gewehr, Mayara C F; Reckziegel, PatriciaMade available in DSpace on 2019-10-06T16:50:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-19; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C5...
15d-PGJ(2)-loaded nanocapsules ameliorate experimental gout arthritis by reduci...
Ruiz-Miyazawa, Kenji W.; Staurengo-Ferrari, Larissa; Pinho-Ribeiro, Felipe A.; Fattori, Victor; Zaninelli, Tiago H.; Badaro-Garcia, StephanieMade available in DSpace on 2018-11-26T17:55:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-09-18; Pesquisa para o Sistema Unico de Saude (PPSUS) grant from Departamento de Ciencia e Tecnologia da Secretaria de Ciencia, Tecnologia e Insumos Estrategicos, Ministerio da Saude (Decit/SCTIE/MS, Brazil); Fundacao Araucaria and Secretaria Estadual de Saude, Parana (SESA-PR, Brazil); Fundação de Amparo à Pe...
Hepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease an...
Spirlandeli, Adriano L.; Dick-de-Paula, Ingrid; Zamarioli, Ariane; Jorgetti, Vanda; Ramalho, Leandra N.Z.; Nogueira-Barbosa, Marcello H.OBJECTIVES: The present study was designed to evaluate the bone phenotypes and mechanisms involved in bone disorders associated with hepatic osteodystrophy. Hepatocellular disease was induced by carbon tetrachloride (CCl4). In addition, the effects of disodium pamidronate on bone tissue were evaluated. METHODS: The study included 4 groups of 15 mice: a) C = mice subjected to vehicle injections; b) C+P = mice su...
TNF-alpha mediates the induction of nitric oxide synthase in macrophages but no...
Fonseca, Simone G; Romão, Pedro R. T.; Figueiredo, Florêncio; Morais, Ruth H.; Lima, Hermênio C.; Ferreira, Sérgio H.; Cunha, Fernando Q.Made available in DSpace on 2016-10-10T03:51:21Z (GMT). No. of bitstreams: 2 TNF mediates the induction of.pdf: 412272 bytes, checksum: 6e70f7e084c3cb97948f0291cf6ffe83 (MD5) license.txt: 1818 bytes, checksum: 46de3043f08e87659ae535ef74b8ce9d (MD5) Previous issue date: 2003-08; Leishmania major infection in C57BL/6 mice is controlled by the activation of a Th1 response and nitric oxide (NO) production by macrop...