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Molecular Profile of Sensitization to Dermatophagoides Pteronyssinus Dust Mite ...

Limão, R; Spínola Santos, A; Araújo, L; Cosme, J; Inácio, F; Tomaz, E; Ferrão, A; Santos, N; Sokolova, A; Môrete, A; Falcão, H; Cunha, L

Background and objectives: To analyze component-resolved diagnosis of sensitization to Dermatophagoides pteronyssinus (Der p) in patients with respiratory allergy and the association between diagnostic findings and clinical severity in different geographical areas. Methods: The study population comprised 217 patients (mean age, 25.85 [12.7] years; 51.16% female) selected from 13 centers in Portugal (5 from the ...


Effects of retaliation techniques in children: A systematic review

Borges, R; Veiga, G.; Bravo, J.; Pereira, C; Cunha, L; Cruz-Ferreira, A

Introduction: Relaxation is a body regulation response, which allows a reduction in blood pressure, oxygen consumption, respiratory and cardiac rhythms and muscle tension, resulting in a feeling of well-being. Objectives: The aim of this systematic review was to know the scientific evidence on the effects of relaxation techniques in children (3-12 years), resulting in five studies included. Methods: The assessm...


Risk factors for oesophageal squamous cell carcinoma in Mozambique

Cunha, L; Fontes, F; Come, J; Lobo, V; Santos, LL; Lunet, N; Carrilho, C

Studies evaluating risk factors for the occurrence of oesophageal squamous cell carcinoma (ESCC) in high-risk regions might contribute to a better understanding of the oesophageal cancer aetiology and incidence variation worldwide. We aimed to quantify the association between alcohol, tobacco and dietary history, and the occurrence of ESCC in Mozambique. A case–control study was conducted at Maputo Central Hosp...


Late Cytomegalovirus Infection in Kidney Transplant Recipients after a Six-Mont...

Cunha, L; Laranjinha, I; Birne, R, et al.

BACKGROUND: Despite a reduction in the incidence of cytomegalovirus (CMV) infections after kidney transplantation, less is known about late CMV infection in kidney transplant recipients. OBJECTIVE: To assess incidence of CMV infection in a cohort of patients under a high surveillance CMV prevention protocol and identify factors associated with late CMV infection. METHODS: Analysis of a consecutive cohort of 181...


Ischemic stroke in patients previously anticoagulated for non-valvular atrial f...

Fernandes, L; Sargento-Freitas, J; Milner, J; Silva, A; Novo, A; Gonçalves, T; Marinho, AV; Mariano Pego, G; Cunha, L; António, N

Oral anticoagulants have proved to be highly effective in preventing atrial fibrillation (AF)-related strokes. The occurrence of stroke despite oral anticoagulation is unexpected and little is known about the mechanisms responsible. The aim of this study was to assess possible mechanisms for stroke occurrence, such as poor treatment adherence and inappropriate dosage, in patients chronically anticoagulated for AF.


Hepatocellular carcinoma: Clinical-pathological features and HIV infection in M...

Cunha, L; Carrilho, C; Bhatt, N; Loforte, M; Maueia, C; Fernandes, F; Guisseve, A; Mbofana, F; Maibaze, F; Mondlane, L; Ismail, M; Dimande, L

Background and aims : Mozambique had been ranked among the countries with the highest global incidence of HCC with chronic hepatitis B infection and high exposure to aflatoxin-B1 (AFB1) being major risk factors. Indeed, HCC remains one of the most frequent cancer in Maputo. On the other hand, Mozambique has a high prevalence of infection with Human Immunodeficiency virus (HIV). Our study aims to describe the ep...


The neural basis of fatigue in multiple sclerosis: A multimodal MRI approach

Novo, AM; Batista, S; Alves, C; d'Almeida, OC; Marques, IB; Macário, C; Santana, I; Sousa, L; Castelo-Branco, M; Cunha, L

BACKGROUND: Fatigue is a frequent disabling symptom in multiple sclerosis (MS), but its pathophysiology remains incompletely understood. This study aimed to explore the underlying neural basis of fatigue in patients with MS. METHODS: We enrolled 60 consecutive patients with MS and 60 healthy controls (HC) matched on age, sex, and education. Fatigue was assessed using the Portuguese version of the Modified Fatig...


Blood Pressure Variability in Acute Ischemic Stroke: The Role of Early Recanali...

Martins, AI; Sargento-Freitas, J; Jesus-Ribeiro, J; Correia, I; Cardoso, L; Gomes, JP; Gonçalves, M; Costa, R; Silva, F; Galego, O; Nunes, C

We performed a retrospective study with the aim of investigating the association between blood pressure (BP) variability in the first 24 h after ischemic stroke and functional outcome, regarding arterial recanalization status. A total of 674 patients diagnosed with acute stroke and treated with revascularization therapies were enrolled. Systolic and diastolic BP values of the first 24 h after stroke were collec...


Collateral pial circulation relates to the degree of brain edema on CT 24 hours...

Galego, O; Jesus-Ribeiro, J; Baptista, M; Sargento-Freitas, J; Martins, AI; Silva, F; Santos, GC; Cunha, L; Nunes, C; Machado, E

Background Cerebral edema is frequent in patients with acute ischemic stroke (AIS) who undergo reperfusion therapy and is associated with high mortality. The impact of collateral pial circulation (CPC) status on the development of edema has not yet been determined. Methods We studied consecutive patients with AIS and documented M1-middle cerebral artery (MCA) and/or distal internal carotid artery (ICA) occlusio...


Aphasia Rapid Test: Translation, Adaptation and Validation Studies for the Port...

Tábuas-Pereira, M; Freitas, S; Beato-Coelho, J; Ribeiro, JA; Parra, J; Martins, C; Silva, M; Matos, MA; Nogueira, AR; Silva, F; Sargento-Freitas, J

Classical aphasia evaluation scales are too long to use in the context of acute stroke or as a monitoring tool. The Aphasia Rapid Test is a 26-point scale developed as a bedside assessment to rate aphasia severity in acute stroke patients in less than 3 minutes. We aimed to adapt and validate this scale for European Portuguese.


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