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Trypanosoma cruzi nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase-1) bi...
Mariotini-Moura, Christiane; Bastos, Matheus Silva e; Castro, Felipe Freitas de; Trindade, Mellina Lanna; Vasconcellos, Raphael de SouzaPrevious work has suggested that Trypanosoma cruzi diphosphohydrolase 1 (TcNTPDase-1) may be involved in the infection of mammalian cells and serve as a potential target for rational drug design. In this work, we produced recombinant TcNTPDase-1 and evaluated its nucleotidase activity, cellular localization and role in parasite adhesion to mammalian host cells. TcNTPDase-1 was able to utilize a broad range of t...
Avaliação da atividade ecto-nucleotidásica de L. infantum e sua modulação na ad...
Cunha, Luana Celina SeraphimCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES; Visceral leishmaniasis is a neglected disease caused by Leishmania infantum in Brazil. The Ecto-NTPDase activities, described in various parasites including Leishmania, is involved in adhesion, infection and virulence of these parasites, functioning as a molecular mechanism able to modulate the host immune response and promoting the disease pr...
Imunolocalização da Nucleosídeo Trifosfato Difosfohidrolase 1 (NTP Dase-1) de T...
Cunha, Luana Celina SeraphimCoordenação de Aperfeiçoamento de Pessoal de Nível Superior; Trypanosoma cruzi is a protozoan of the Order Kinetoplastida, etiologic agent of Chagas disease. The ecto-nucleotidases of the E-NTPDases family are enzymes able to hydrolyze nucleotide tri-and / or diphosphates in their monophosphate products. Nucleotides are known as extracellular signaling molecules involved in various cellular processes, including...
Trypanosoma cruzi nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase-1) bi...
Moura, Christiane Mariotini; Bastos, Matheus Silva e; Castro, Felipe Freitas de; Trindade, Mellina Lanna; Vasconcellos, Raphael de SouzaPrevious work has suggested that Trypanosoma cruzi diphosphohydrolase 1 (TcNTPDase-1) may be involved in the infection of mammalian cells and serve as a potential target for rational drug design. In this work, we produced recombinant TcNTPDase-1 and evaluated its nucleotidase activity, cellular localiza- tion and role in parasite adhesion to mammalian host cells. TcNTPDase-1 was able to utilize a broad range of...