4 documents found, page 1 of 1
Cutaneous Lesions as the First Manifestation of Multiple Myeloma: Two Case Reports
Kieselová, Katarína; Santiago, Felicidade; Ramos, Sofia; Cunha, Maria Fernanda; Henrique, MartinhaMultiple myeloma is a proliferative clonal disorder of plasma cells. The clinical presentation is highly variable, with recurrent infections, anemia, renal insufficiency or bone pain from osteolytic lesions as the main initial manifestations. Skin manifestations are unusual and mostly unspecific. We describe two patients with cutaneous lesions as the first sign of this hematologic malignancy: nodular deposits o...
Dermoscopy in Merkel Cell Carcinoma: A Case Report
Guiote Domínguez, Victoria; Cunha, Maria FernandaMerkel cell carcinoma is a rare neuroendocrine tumor localized in photo-exposed areas in aged adults. A high risk of local recurrence, early metastatic disease and, frequently, a late diagnosis, are determinant of a poor prognosis. Dermoscopic examination of this lesion, which is characterized by the presence of multiple atypical vessels and “red-milky areas”, might be a very useful tool to suspect the diagnosi...
Anti-inflammatory, anti-proliferative and antioxidant profiles of selective cyc...
Parada, Belmiro; Sereno, Jose; Reis, Flavio; Teixeira-Lemos, Edite; Garrido, Patricia; Pinto, Angela Filipa; Cunha, Maria Fernanda; Pinto, RuiPurpose: To evaluate the efficacy of a selective cyclooxygenase-2 (COX-2) inhibitor in rat bladder cancer chemoprevention, as well as to assess the relevance of inflammation, proliferation and oxidative stress in tumor growth and in its prevention. Results: The main findings were: (I) the incidence of carcinoma was: control: 0% (0/8); BBN: 65% (13/20); CEL: 0% (0/8) and BBN + CEL: 12.5% (1/8); (II) the mean tum...
Trabecular tumour of the Thyroid: adenoma or papillary carcinoma? A clinical ca...
Ponte, Alcina; Henriques, Margarida; Mendes, António; Ferrão, Ana; Cunha, Maria Fernanda; Gonçalves, MornaThe authors describe a case of a young woman with a thyroid mass. Fine needle aspiration of the thyroid revealed a Hürthle cell tumour. Histologic diagnosis was papillar carcinoma – trabecular variant. Hyalinizing trabecular adenoma (HTA) is a follicle-derived tumour of the thyroid gland and has been described as benign. Currently, discussions are underway to decide whether or not HTA should be regarded as a tr...