111 documents found, page 1 of 12
Genetic polymorphisms of P2RX7 but not of ADORA2A are associated with the sever...
Lindo, Jorge; Nogueira, Célia; Soares, Rui; Cunha, Nuno; Almeida, Maria Rosário; Rodrigues, Lisa; Coelho, Patrícia; Rodrigues, FranciscoSARS-CoV-2 infection ranges from mild to severe presentations, according to the intensity of the aberrant inflammatory response. Purinergic receptors dually control the inflammatory response: while adenosine A2A receptors (A2ARs) are anti-inflammatory, ATP P2X7 receptors (P2X7Rs) exert pro-inflammatory effects. The aim of this study was to assess if there were differences in allelic and genotypic frequencies of...
Genetic polymorphisms of P2RX7 but not of ADORA2A are associated with the sever...
Lindo, Jorge; Nogueira, Célia; Soares, Rui; Cunha, Nuno; Almeida, Maria Rosário; Rodrigues, Lisa; Coelho, Patricia; Rodrigues, FranciscoSARS-CoV-2 infection ranges from mild to severe presentations, according to the intensity of the aberrant inflammatory response. Purinergic receptors dually control the inflammatory response: while adenosine A2A receptors (A2ARs) are anti-inflammatory, ATP P2X7 receptors (P2X7Rs) exert pro-inflammatory effects. The aim of this study was to assess if there were differences in allelic andgenotypic frequencies of ...
Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Ade...
Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel; Gonçalves, NélioIncreased ATP release and its extracellular catabolism through CD73 (ecto-5'-nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in different brain disorders. A2AR blockade blunts mood and memory dysfunction caused by repeated stress, but it is unknown if increased ATP release coupled to CD73-mediated formation of extracellular adenosine is responsible for A2AR overactivatio...
Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic In...
Lopes, Cátia R.; Gonçalves, Francisco Q.; Olaio, Simão; Tomé, Ângelo R.; Cunha, Rodrigo A.; Lopes, João PedroAdenosine operates a modulation system fine-tuning the efficiency of synaptic transmission and plasticity through A1 and A2A receptors (A1R, A2AR), respectively. Supramaximal activation of A1R can block hippocampal synaptic transmission, and the tonic engagement of A1R-mediated inhibition is increased with increased frequency of nerve stimulation. This is compatible with an activity-dependent increase in extrac...
Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticost...
Gonçalves, Francisco Q.; Matheus, Filipe C.; Silva, Henrique B.; Real, Joana I.; Rial, Daniel; Rodrigues, Ricardo J.; Oses, Jean-PierreExtracellular ATP can be a danger signal, but its role in striatal circuits afflicted in Parkinson's disease (PD) is unclear and was now investigated. ATP was particularly released at high stimulation intensities from purified striatal nerve terminals of mice, which were endowed with different ATP-P2 receptors (P2R), although P2R antagonists did not alter corticostriatal transmission or plasticity. Instead, ATP...
Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potenti...
Lopes, Cátia R.; Silva, Joana S; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; Lourenço, Vanessa S.Alzheimer's disease (AD), which predominantly affects women, involves at its onset a metabolic deregulation associated with a synaptic failure. Here, we performed a behavioral, neurophysiological and neurochemical characterization of 9-month-old female APPswe/PS1dE9 (APP/PS1) mice as a model of early AD. These animals showed learning and memory deficits in the Morris water maze, increased thigmotaxis and anxiet...
Coffee consumption decreases the connectivity of the posterior Default Mode Net...
Picó-Pérez, Maria; Magalhães, Ricardo; Esteves, Madalena; Vieira, Rita; Castanho, Teresa C.; Amorim, Liliana; Sousa, Mafalda; Coelho, AnaHabitual coffee consumers justify their life choices by arguing that they become more alert and increase motor and cognitive performance and efficiency; however, these subjective impressions still do not have a neurobiological correlation. Using functional connectivity approaches to study resting-state fMRI data in a group of habitual coffee drinkers, we herein show that coffee consumption decreased connectivit...
The striatum drives the ergogenic effects of caffeine
de Bem Alves, Ana Cristina; Speck, Ana Elisa; Farias, Hémelin Resende; Martins, Leo Meira; Dos Santos, Naiara Souza; Pannata, GabrielaCaffeine is one of the main ergogenic resources used in exercise and sports. Previously, we reported the ergogenic mechanism of caffeine through neuronal A2AR antagonism in the central nervous system [1]. We now demonstrate that the striatum rules the ergogenic effects of caffeine through neuroplasticity changes. Thirty-four Swiss (8-10 weeks, 47 ± 1.5 g) and twenty-four C57BL/6J (8-10 weeks, 23.9 ± 0.4 g) adul...
Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Ad...
Lopes, Cátia R.; Oliveira, Andreia; Gaspar, Ingride L.; Rodrigues, Matilde S.; Santos, Joana; Szabó, Eszter; Silva, Henrique B.; Tomé, Ângelo R.Adenosine receptors mainly control synaptic function, and excessive activation of adenosine receptors may worsen the onset of many neurological disorders. Accordingly, the regular intake of moderate doses of caffeine antagonizes adenosine receptors and affords robust neuroprotection. Although caffeine intake alters brain functional connectivity and multi-omics analyses indicate that caffeine intake modifies syn...
Lateral septum adenosine A2A receptors control stress-induced depressive-like b...
Wang, Muran; Li, Peijun; Li, Zewen; Silva, Beatriz S. da; Zheng, Wu; Xiang, Zhenghua; He, Yan; Xu, Tao; Cordeiro, Cristina; Deng, Lu; Dai, YuweiMajor depressive disorder ranks as a major burden of disease worldwide, yet the current antidepressant medications are limited by frequent non-responsiveness and significant side effects. The lateral septum (LS) is thought to control of depression, however, the cellular and circuit substrates are largely unknown. Here, we identified a subpopulation of LS GABAergic adenosine A2A receptors (A2AR)-positive neurons...