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Interaction of a Homologous Series of Amphiphiles with P-glycoprotein in a Memb...
Moreno, Maria João; Filipe, Hugo A. L.; Cunha, Susana V. P.; Ramos, Cristiana V.; Martins, Patricia A. T.; Abel, Biebele; Loura, Luís M. S.The transport of drugs by efflux transporters in biomembranes limits their bioavailability and is a major determinant of drug resistance development by cancer cells and pathogens. A large number of chemically dissimilar drugs are transported, and despite extensive studies, the molecular determinants of substrate specificity are still not well understood. In this work, we explore the role of polar and non-polar ...
Date: 2023
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Origin: Estudo Geral - Universidade de Coimbra