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Joint production of IL-22 participates in the initial phase of antigen-induced ...

Pinto, Larissa G.; Talbot, Jhimmy; Peres, Raphael S.; Franca, Rafael F.; Ferreira, Sérgio Henrique; Ryffel, Bernhard; Alves-Filho, José Carlos F.

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by neutrophil articular infiltration, joint pain and the progressive destruction of cartilage and bone. IL-22 is a key effector molecule that plays a critical role in autoimmune diseases. However, the function of IL-22 in the pathogenesis of RA remains controversial. In this study, we investigated the role of IL-22 in the earl...

Date: 2021   |   Origin: Oasisbr








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