2 documents found, page 1 of 1
Cebranopadol, a first-in-class investigational opioid: Insights from preliminar...
Almeida, Margarida; Diogo , Beatriz; Rocha , Joana; Dinis-Oliveira , Ricardo Jorge; Cunha , Andrea; Faria , Juliana; Barbosa, JoanaBackground: Cebranopadol, a promising opioid analgesic undergoing phase III trials, was developed for the treatment of acute and chronic moderate-to-severe pain. Because it is a non-selective ligand acting at more than one member of the opioid receptor family, combining a dual agonist action on mu-, delta-, and kappa-opioid receptors (MOR, DOR, and KOR) and nociceptin/orphanin FQ peptide (NOP) receptors, it has...
Assessment of the Antitumor Potential of Flavonoid-Amino Acid Conjugates
Barbosa , Flávia; Cunha , Andrea; Pinto , Cláudia; Bousbaa , Hassan; Cidade , Honorina; Silva , Patrícia M. A.; Tiritan , Maria ElizabethBackground: Cancer is a complex disease characterized by multiple alterations that promote uncontrolled cell proliferation and resistance to cell death. Multidrug resistance to conventional chemotherapy often results in treatment failure, highlighting the need for alternative therapeutic strategies [1]. In this context, natural products and their derivatives have attracted significant interest for their potenti...