3 documents found, page 1 of 1
Determinação dos níveis de anticorpos séricos e salivares AntiPGL-1 de contatos...
Cunha Júnior, José EvandroLeprosy is considered a serious public health problem due to its difficult epidemiological control and the risk of causing major physical disabilities. Investigation of serological markers, such as the anti-PGL-1 antibody, targeting a glycolipid present on the cell wall of the leprosy-causing bacteria, has been of paramount importance in investigating exposure to bacillus and estimating exposure time to same. T...
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium lepra...
Macedo, Alexandre Casimiro de; Cunha Júnior, José Evandro; Yaochite, Juliana Navarro Ueda; Tavares, Clodis Maria; Nagao-Dias, Aparecida TiemiConsidering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4–16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alago...
Anti-PGL1 salivary IgA/IgM, serum IgG/IgM, and nasal Mycobacterium leprae DNA i...
Cabral, Paula Brito e; Cunha Júnior, José Evandro; Macedo, Alexandre Casimiro de; Gondim, Ana Paula Soares; Pinto, Maria Isabel MoraesObjectives: Leprosy household contacts represent a group at high risk of developing the disease. The aim of this study was to detect Mycobacterium leprae subclinical infection in this group through serological and molecular parameters. Methods: Serum anti-PGL1 IgG/IgM and salivary anti-PGL1 IgA/IgM was investigated using an ELISA, and nasal carriage of M. leprae DNA was detected by PCR, in leprosy household con...