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Different risk profiles for progression of nonproliferative diabetic retinopath...
Marques, Inês P.; Ribeiro, Maria L.; Santos, Torcato P.; Mendes, Luis G.; Reste-Ferreira, Débora; Santos, Ana Rita; Lobo, Conceição L.Characterization of 2-year progression of different risk phenotypes in eyes with mild and moderate nonproliferative diabetic retinopathy (NPDR) in type 2 diabetes (T2D). A 2-year prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted. Ophthalmological examinations were performed including best corrected visual acuity, color fundus photography and optical coherence tomography (OCT and OCTA). O...
Swept-source OCTA quantification of capillary closure predicts ETDRS severity s...
Santos, Torcato; Warren, Lewis H.; Santos, Ana Rita B. M.; Marques, Inês Pereira; Kubach, Sophie; Mendes, Luís G.; Sisternes, Luís de; Madeira, Maria H.To test whether a single or composite set of parameters evaluated with optical coherence tomography angiography (OCTA), representing retinal capillary closure, can predict non-proliferative diabetic retinopathy (NPDR) staging according to the gold standard ETDRS grading scheme. 105 patients with diabetes, either without retinopathy or with different degrees of retinopathy (NPDR up to ETDRS grade 53), were prosp...
Measurements of retinal fluid by oct leakage in diabetic macular edema: A bioma...
Santos, Ana Rita; Alves, Dalila; Santos, Torcato; Figueira, João; Rufino, Silva; Cunha-Vaz, José G.Optical coherence tomography leakage changes after anti-vascular endothelial growth factor treatment of diabetic macular edema, identifying the degree of decrease in retinal fluid in the outer layers of the retina is a more robust biomarker of BCVA recovery than central retinal thickness, disorganization of the inner retinal layer, or ellipsoid zone disruption changes.
Macular alterations after small-incision cataract surgery
Lobo, Conceição L.; Faria, Pedro M.; Soares, Mário A.; Bernardes, Rui C.; Cunha-Vaz, José G.Purpose: To characterize macular edema that occurs after uneventful cataract surgery.; http://www.sciencedirect.com/science/article/B6VSF-4C54BTG-N/1/fba2fd923592d5172c5e0a4f69426a61
Stabilization of visual acuity with photodynamic therapy in eyes with chorioret...
Silva, Rufino M.; Abreu, José R. Faria de; Travassos, António; Cunha-Vaz, José G.Purpose(1) To evaluate, in a non-randomized, institutional, prospective study, the efficacy of photodynamic therapy with Visudyne (PDT) in neovascular age-related macular degeneration (AMD) eyes with chorioretinal anastomoses (CRA). (2) To review, in a retrospective study and for comparison, the natural evolution of neovascular AMD eyes with CRA.MethodsProspective clinical and angiographic study of 17 consecuti...
Effect of cyclosporin-A on the blood-retinal barrier permeability in streptozot...
Carmo, Anália; Cunha-Vaz, José G.; Carvalho, Arsélio P.; Lopes, Maria CelesteBACKGROUND: Our previous results showed that in retinas from streptozotocin (STZ)-induced diabetic rats there is an increased level of interleukin-1beta (IL-1beta). This cytokine may be involved in the expression of the inducible isoform of the nitric oxide synthase (iNOS), with consequent synthesis of large amounts of NO and blood-retinal barrier (BRB) breakdown. AIMS: The aim of this work was to examine wheth...
Measuring retinal fluorescein leakage into the human vitreous with a modified c...
Bernardes, Rui C.; Lobo, Conceição L.; Cunha-Vaz, José G.A method is described to quantify blood-retinal barrier permeability to fluorescein. Data are collected from the vitreous of the human eye at two elapsed time intervals after intravenous fluorescein administration, using a modified confocal scanning laser ophthalmoscope. Data processing includes fundus image enhancement, image alignment, profile construction, filtering and interpolation, exponential fit and int...