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BDNF regulates the expression and distribution of vesicular glutamate transport...

Melo, Carlos V.; Mele, Miranda; Curcio, Michele; Comprido, Diogo; Silva, Carla G.; Duarte, Carlos B.

BDNF is a pro-survival protein involved in neuronal development and synaptic plasticity. BDNF strengthens excitatory synapses and contributes to LTP, presynaptically, through enhancement of glutamate release, and postsynaptically, via phosphorylation of neurotransmitter receptors, modulation of receptor traffic and activation of the translation machinery. We examined whether BDNF upregulated vesicular glutamate...

Date: 2013   |   Origin: Estudo Geral - Universidade de Coimbra
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