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SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells ty...
Gomes, André; Farias, Guilherme B.; Dias Silva, Manuel; Laia, Joel; Trombetta, Amelia Chiara; Godinho-Santos, Ana; Rosmaninho, Pedro; Santos, Diana F.Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of ci...
Acute HIV-1 and SARS-CoV-2 infections Share Slan+ Monocyte Depletion - evidence...
Farias, Guilherme B.; Badura, Robert; Conceição, Carolina M.; Gomes, André; Godinho-Santos, Ana; Laia, Joel; Rosmaninho, Pedro; Santos, DianaMonocytes are key modulators in acute viral infections, determining both inflammation and development of specific B- and T-cell responses. Recently, these cells were shown to be associated to different SARS-CoV-2 infection outcome. However, their role in acute HIV-1 infection remains unclear. We had the opportunity to evaluate the mononuclear cell compartment in an early hyper-acute HIV-1 patient in comparison ...
Severe COVID-19 recovery is associated with timely acquisition of a myeloid cel...
Trombetta, Amelia Chiara; Farias, Guilherme B.; Gomes, André; Godinho-Santos, Ana; Rosmaninho, Pedro; Conceição, Carolina M.; Laia, JoelAfter more than one year since the COVID-19 outbreak, patients with severe disease still constitute the bottleneck of the pandemic management. Aberrant inflammatory responses, ranging from cytokine storm to immune-suppression, were described in COVID-19 and no treatment was demonstrated to change the prognosis significantly. Therefore, there is an urgent need for understanding the underlying pathogenic mechanis...
The dysfunctional immune system in common variable immunodeficiency increases t...
Gullo, Irene; Costa, Catarina; Silva, Susana L.; Ferreira, Cristina; Motta, Adriana; Silva, Sara P.; Duarte Ferreira, Ruben; Rosmaninho, PedroGastric carcinoma (GC) represents the most common cause of death in patients with common variable immunodeficiency (CVID). However, a limited number of cases have been characterised so far. In this study, we analysed the clinical features, bacterial/viral infections, detailed morphology and immune microenvironment of nine CVID patients with GC. The study of the immune microenvironment included automated digital...
Monozygotic twins concordant for common variable immunodeficiency : strikingly ...
Silva, Susana L.; Fonseca, Mariana; Pereira, Marcelo L. M.; Silva, Sara P.; Barbosa, Rita R.; Serra-Caetano, Ana; Blanco, Elena; Rosmaninho, PedroMonozygotic twins provide a unique opportunity to better understand complex genetic diseases and the relative contribution of heritable factors in shaping the immune system throughout life. Common Variable Immunodeficiency Disorders (CVID) are primary antibody defects displaying wide phenotypic and genetic heterogeneity, with monogenic transmission accounting for only a minority of the cases. Here, we report a ...
Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-ep...
Singh, Shalini; Howell, Danielle; Trivedi, Niraj; Kessler, Ketty; Ong, Taren; Rosmaninho, Pedro; Raposo, Alexandre ASF; Robinson, GilesIn the developing mammalian brain, differentiating neurons mature morphologically via neuronal polarity programs. Despite discovery of polarity pathways acting concurrently with differentiation, it's unclear how neurons traverse complex polarity transitions or how neuronal progenitors delay polarization during development. We report that zinc finger and homeobox transcription factor-1 (Zeb1), a master regulator...
Gene Regulation by the transcription factor ZEB1 in Glioblastoma Multiforme
Rosmaninho, PedroGlioblastoma Multiforme (GBM) is the most prevalent type of glioma, bearing the highest incidence rate of brain and Central Nervous System (CNS) malignant tumors and the lowest survival rate. GBMs distinguish themselves from lower grade glial tumors by the presence of certain hallmark histological features such as the presence of central necrosis in the tumor mass, marginal proliferation of endothelial cells an...