Encontrados 2 documentos, a visualizar página 1 de 1
Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the...
Spencer, AP; Torrado, M; Custódio, B; Silva-Reis, SC; Santos, S; Leiro, V; Pêgo, APCentral nervous system (CNS) disorders encompass a vast spectrum of pathological conditions and represent a growing concern worldwide. Despite the high social and clinical interest in trying to solve these pathologies, there are many challenges to bridge in order to achieve an effective therapy. One of the main obstacles to advancements in this field that has hampered many of the therapeutic strategies proposed...
PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal...
Santos, SD; Xavier, M; Leite, D; Moreira, D; Custódio, B; Torrado, M; Castro, R; Leiro, V; Rodrigues, J; Tomás, H; Pêgo, APDrug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing a window of opportunity to passively target the brain. Here, cationic poly(amido amine) (PAMAM) dendrimers of different generations were functionalized with poly(ethylene glycol) (PEG) to reduce cytotoxicity and prolong blood circulation half-life, aimin...