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Desafio imune neonatal com lipopolissacarídeo desencadeia alterações comportame...
Custódio, Charllyany SabinoEarly life adversities, such as infections and stress, are related to the manifestation of neuropsychiatric disorders, such as autism and schizophrenia. These changes may be triggered by inflammatory and / or neurotrophic mechanisms. In this context, we decided to carry out a wide range of behavioral and neurobiological tests, such as the participation of indolamine 2,3-dioxygenase (IDO) - the first tryptophan ...
Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting sex- an...
Custódio, Charllyany Sabino; Mello, Bruna Stefânia Ferreira; Chaves Filho, Adriano José Maia; Lima, Camila Nayane de CarvalhoEarly-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic...
Time course of the effects of lipopolysaccharide on prepulse inhibition and bra...
Custódio, Charllyany Sabino; Mello, Bruna Stefânia Ferreira; Cordeiro, Rafaela Carneiro; Araújo, Fernanda Yvelize Ramos de; Chaves, João HenriqueThe systemic administration of lipopolysaccharide (LPS) induces time-dependent behavioral alterations, which are related to sickness behavior and depression. The time-course effects of LPS on prepulse inhibition (PPI) remain unknown. Furthermore, the time-dependent effects of LPS on central nitrite content had not been investigated. Therefore, we studied alterations induced by single LPS (0.5 mg/kg, i.p.) admin...
Estudo de alterações comportamentais e neuroinflamatórias induzidas pela admini...
Custódio, Charllyany SabinoBased on evidences that systemic administration of lipopolysaccharide (LPS) in animals can trigger time-dependent pathophysiological changes, which together are named sickness behavior and depression, we sought to determine by immune challenge with systemic administration of LPS (0.5 mg / kg, ip) in male mice, the behavioral changes on parameters such as: behavior related to depression and anxiety, pre-pulse in...