The present study aimed to perform molecular, histomorphological and immunohistochemical analysis of oral pathogens in healthy cardiac valves and calcified aortic stenosis, as well as evaluate the expression of Osteopontin, Fibrinogen, CD61 and inflammatory markers in these samples. Dental plaque, saliva and heart valve samples from ten patients with calcified aortic stenosis were collected for molecular analys...
OBJECTIVES: To evaluate the expression of p-AKT, p-JNK, FoxO3a and KI-67 in samples of Oral Squamous Cell Carcinoma (OSCC) and Oral Epithelial Dysplasias (OEDs) to understand their possible involvement in the malignant transformation process of oral lesions. MATERIALS AND METHODS: Tissue samples of 20 cases of OSCCs, 20 OEDs and normal oral mucosa were subjected to immunohistochemistry reactions for anti-p-Akt,...
Abstract: Structural deficiencies and functional abnormalities of heart valves represent an important cause of cardiovascular morbidity and mortality, and a number of diseases, such as aortic stenosis, have been recently associated with infectious agents. This study aimed to analyze oral bacteria in dental plaque, saliva, and cardiac valves of patients with cardiovascular disease. Samples of supragingival plaqu...
Aim: To present the clinical findings of a patient with Fibrodysplasia Ossificans Progressiva (FOP), highlighting peculiarities of dental treatment in patients with this condition. Background: FOP is a rare genetic disease characterized by skeletal malformations and ectopic ossifications in skeletal muscles, tendons, ligaments and aponeurosis. Exacerbation of these ossifications can be caused by dental treatmen...
Background: Oral bacteria have been detected in atherosclerotic plaques at a variable frequency; however, the connection between oral health and vascular and oral bacterial profiles of patients with vascular disease is not clearly established. The aim of this study was to evaluate the presence of oral bacterial DNA in the mouth and atherosclerotic plaques, in addition to assessing the patients’ caries and perio...
Ao longo dos últimos anos, tem havido cada vez mais provas do efeito da saúde bucal sobre a saúde geral dos indivíduos, suportadas por uma série de estudos biológicos e epidemiológicos que mostram uma relação entre a boca e muitas doenças, incluindo as doenças cardiovasculares. Deficiências estruturais e anormalidades funcionais de válvulas cardíacas representam uma importante causa de morbidade e mortalidade c...
Primary cardiac angiosarcoma is an extremely rare malignant tumor. Distant metastases are common at the time of diagnosis but have never been reported in the jaw. A 45-year-old female patient with primary cardiac angiosarcoma was referred for dental care due to pain in the mandibular alveolar ridge. Oral examination revealed a red-violet lesion that was soft on palpation and had been present for 3 months. Histo...
Objective To evaluate the oral health status of a population of patients with special needs cared for in the specialization course of the Brazilian Association of Dentistry, Ceará Branch. Methods In this cross-sectional, descriptive study the indexes DMFT and CPI were used to evaluate dental caries and periodontal disease, respectively, from August 2009 through March 2010. The need for dental treatment and othe...
Objective To evaluate the oral health status of a population of patients with special needs cared for in the specialization course of the Brazilian Association of Dentistry, Ceará Branch. Methods In this cross-sectional, descriptive study the indexes DMFT and CPI were used to evaluate dental caries and periodontal disease, respectively, from August 2009 through March 2010. The need for dental treatment and othe...