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Targeting NF-κB signaling pathway in cancer by dietary polyphenols

Khan, Haroon; Ullah, Hammad; Castilho, Paula Cristina Machado Ferreira; Gomila, Antoni Sureda; D'Onofrio, Grazia; Filosa, Rosanna; Wang, Fang

Being a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role in the development of inflammation and cancer. Thus, the down-regulation of NF-κB may be an exciting target in prevention and treatment of cancer. NF-κB could act as a tumor activator or tumor suppressant decided by ...


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