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Safety and Outcomes of Routine Endovascular Thrombectomy in Large Artery Occlus...

Ahmed, N.; Mazya, M.; Paiva Nunes, A; Moreira, T; Ollikainen, JP; Escudero‐Martinez, I; Bigliardi, G; Dorado, L; Dávalos, A; Egido, JA; Tassi, R

Background and objective: We aimed to evaluate the safety and outcomes of thrombectomy in anterior circulation acute ischaemic stroke recorded in the SITS-International Stroke Thrombectomy Register (SITS-ISTR) and compare them with pooled randomized controlled trials (RCTs) and two national registry studies. Methods: We identified centres recording ≥10 consecutive patients in the SITS-ISTR with at least 70% of ...


Citicoline in the treatment of acute ischaemic stroke: an international, random...

Dávalos, A; Alvarez-Sabin, J; Castillo, J; Diez-Tejedor, E; Ferro, J; Martinez-Vila, E; Serena, J; Segura, T; Cruz, V; Masjuan, J; Cobo, E; Secades, J

BACKGROUND: Citicoline is approved in some countries for the treatment of acute ischaemic stroke. The drug has shown some evidence of efficacy in a pooled analysis. We sought to confirm the efficacy of citicoline in a larger trial. METHODS: We undertook a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke admitted at university hospitals in Germany, Portu...


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