4 documents found, page 1 of 1
A case of success: complete response to Radium-223 in metastatic castration-res...
Soares De Pinho, Inês; Esperança Martins, Miguel; Machado, Bárbara; Dâmaso, Sara; Brás, Raquel; Cantinho, Guilhermina; Fernandes, Isabel; Costa, LuisRadium-223 dichloride (Ra223) is the first targeted alpha agent approved for treating metastatic castration-resistant prostate cancer (mCRPC) with bone-exclusive disease. A benefit in overall survival and time to the first symptomatic skeletal-related event was shown in the Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial. However, this trial did not describe a bone scan response to Ra223, an...
ÍNDICE DE RESPOSTA INFLAMATÓRIA SISTÉMICA COMO FATOR PROGNÓSTICO EM DOENTES COM...
Dâmaso, Sara; Paiva, Rita; Pinho, Inês; Martins, Miguel Esperança; Brás, Raquel Lopes; Costa, Ana Lúcia; Quintela, António; Pinto, ConceiçãoINTRODUÇÃO O adenocarcinoma do pâncreas (PDAC) apresenta-se como um tumor sólido com prognóstico extremamente desfavorável, tendo uma sobrevida global (OS) aos 5 anos de aproximadamente 5%. Na doença metastizada, os esquemas de quimioterapia (QT) aprovados em primeira linha são variados, maioritariamente à base de platino ou gemcitabina. O índice de resposta inflamatória sistémica (SIRI) consiste num scor...
Expression of receptor activator of NFkB (RANK) drives stemness and resistance ...
Fernandes Gomes, Inês; Almeida, Bernardo P. De; Dâmaso, Sara; Mansinho, André; Correia, Inês; Henriques, Sara; Duarte, Raquel; Vilhais, GuilhermeThe role of RANKL-RANK pathway in progesterone-driven mammary carcinogenesis and triple negative breast cancer tumorigenesis has been well characterized. However, and despite evidences of the existence of RANK-positive hormone receptor (HR)-positive breast tumors, the implication of RANK expression in HR-positive breast cancers has not been addressed before. Here, we report that RANK pathway affects the express...
Collagen biology making inroads into prognosis and treatment of cancer progress...
Martins Cavaco, Ana C.; Dâmaso, Sara; Casimiro, Sandra; Costa, LuisProgression through dissemination to tumor-surrounding tissues and metastasis development is a hallmark of cancer that requires continuous cell-to-cell interactions and tissue remodeling. In fact, metastization can be regarded as a tissue disease orchestrated by cancer cells, leading to neoplastic colonization of new organs. Collagen is a major component of the extracellular matrix (ECM), and increasing evidenc...