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Genetic variants in oxidative stress-related genes and their impact on prognosi...

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasia characterized by the BCR::ABL1 fusion gene, which codifies the BCR-ABL protein with increased tyrosine kinase activity. Despite the clinical results for the outstanding tyrosine kinase inhibitors (TKIs), drug resistance is a problem in CML management. Genetic variants that alter redox homeostasis by changing antioxidant enzyme expression or...

Genetic variants of ABC and SLC transporter genes and chronic myeloid leukaemia...

Solute carrier (SLC) and ATP-binding cassette (ABC) transporters comprise a variety of proteins expressed on cell membranes responsible for intrusion or extrusion of substrates, respectively, including nutrients, xenobiotics, and chemotherapeutic agents. These transporters mediate the cellular disposition of tyrosine kinase inhibitors (TKIs), and their genetic variants could affect its function, potentially pre...

DNA Methylation Is Correlated with Oxidative Stress in Myelodysplastic Syndrome...

Oxidative stress and abnormal DNA methylation have been implicated in cancer, including myelodysplastic syndromes (MDSs). This fact leads us to investigate whether oxidative stress is correlated with localized and global DNA methylations in the peripheral blood of MDS patients. Sixty-six MDS patients and 26 healthy individuals were analyzed. Several oxidative stress and macromolecule damage parameters were anal...

Flow cytometry and targeted immune transcriptomics identify distinct profiles i...

Background: Tumor cells have evolved complex strategies to escape immune surveillance, a process which involves NK cells and T lymphocytes, and various immunological factors. Indeed, tumor cells recruit immunosuppressive cells [including regulatory T-cells (Treg), myeloid-derived suppressor cells (MDSC)] and express factors such as PD-L1. Molecularly targeted therapies, such as imatinib, have off-target effects...

Flow cytometry and targeted immune transcriptomics identify distinct profiles i...

BACKGROUND: Tumor cells have evolved complex strategies to escape immune surveillance, a process which involves NK cells and T lymphocytes, and various immunological factors. Indeed, tumor cells recruit immunosuppressive cells [including regulatory T-cells (Treg), myeloid-derived suppressor cells (MDSC)] and express factors such as PD-L1. Molecularly targeted therapies, such as imatinib, have off-target effects...

Association Between Anthropometric Parameters and Glycemic Control in Type 2 Di...

Introduction: Body measurements are attractive tools, due totheir low cost and easy applicability. The aim of this study isto characterize the anthropometric measures of a diabeticpopulation and to analyze the relationship with hemoglobinA1c (HbA1c).Material and Methods: A prospective, observational study included patients followed in a Diabetology consultation. Statistical analysis was performed using the SPSS...

Fibrinolysis in a District Hospital: Performance of the First Two Years

Introduction: Fibrinolysis is a therapy of ischemic stroke andits precocity relates to the prognosis. In this paper we analyzed the performance times in the first two years of the “codestroke” rapid access protocol patients undergoing fibrinolysis.Material and Methods: Prospective and observational studywith data from 1 July 2015 to 30 June 2017. We performeddescriptive analysis and inferential statistics. The ...

Internal Medicine at the District Hospital of Figueira da Foz

Emergency Medical Service Vehicle: Data From the Hospital Distrital da Figueira...

Introduction: Introduction: Pre-hospital emergency care isaimed to provide adequate treatment to the population in occurrences of sudden disease or trauma, on-site stabilizationof the patient and, if necessary, ensuring the safe transportto the health unit.Material and Methods: Here, we describe the activity of viatura médica de emergência e reanimação, an emergencymedical service vehicle, from the Hospital Dis...

The “Hidden” Gallbladder