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Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PG...
Pereira, AS; Gouveia, Alexandra; Tomada, N; Rodrigues, AR; D NevesCardiovascular disease risk factors (CVDRF), especially diabetes mellitus (DM), disrupt oxidative stress response. This condition underlies endothelial dysfunction, early manifested in men as erectile dysfunction. The current study is aimed at elucidating the impact of CVDRF in the oxidation responsive AMPK/SIRT1-PGC-1 alpha-SIRT3 pathway and related miRNAs in the human corpus cavernosum. Human penile tissue fr...
Characterization of TGF-ß expression and signaling profile in the adipose tissu...
Sousa-Pinto, Bernardo; Goncalves, Laura; Rodrigues, Adriana R.; Tomada, Inês; Almeida, Henrique; D Neves; Gouveia, AlexandraTransforming growth factor beta (TGF-ß) plays an important role in the pathogenesis of obesity, influencing the release of inflammation mediators and promoting remodeling and collagen deposition in the adipose tissue (AT). In this context, this work aims to elucidate whether TGF-ß and Smad-dependent or Smad-independent signaling pathways contribute to regional differentiation of AT in high-fat diet (HFD) and en...